Academic Journal
Voluntary exercise in mesothelioma : effects on tumour growth and treatment response in a murine model
| العنوان: | Voluntary exercise in mesothelioma : effects on tumour growth and treatment response in a murine model |
|---|---|
| المؤلفون: | Fisher, Scott A., Peddle-McIntyre, Carolyn J., Burton, Kimberley, Newton, Robert U., Marcq, Elly, Lake, Richard A., Nowak, Anna K. |
| المصدر: | 1756-0500 ; BMC research notes |
| سنة النشر: | 2020 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Biology, Human medicine, Engineering sciences. Technology |
| الوصف: | Objective There is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations. Long latency periods associated with carcinogen–induced cancers like asbestos induced mesothelioma provide an opportunity to implement exercise as an intervention to delay or prevent disease development. However, there are limited studies investigating the ability of exercise to prevent or delay cancer, and exercise as a preventive strategy has never been assessed in models with a known carcinogen. We investigated the potential of voluntary exercise (VE) to delay development of asbestos related disease (ARD) in our well-characterised, asbestos induced MexTAg model of mesothelioma. Results Asbestos exposed MexTAg mice were given continuous or delayed access to VE and ARD assessed over time. We found that the addition of VE did not affect ARD development in asbestos exposed MexTAg mice. However, non–asbestos exposed, aged matched control mice participated in significantly more VE behaviours, suggesting subclinical development of ARD after asbestos exposure had a greater impact on VE participation than age alone. These data highlight the importance of model choice and the potential limitation that some pre–clinical studies may not accurately represent the clinical paradigm, particularly in the context of prevention studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isi/000573036100004 |
| الاتاحة: | https://hdl.handle.net/10067/1746730151162165141 https://repository.uantwerpen.be/docstore/d:irua:4152 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7CF4C235 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |