Academic Journal
What is the role of the new index relative fat mass (RFM) in the assessment of nonalcoholic fatty liver disease (NAFLD)?
| العنوان: | What is the role of the new index relative fat mass (RFM) in the assessment of nonalcoholic fatty liver disease (NAFLD)? |
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| المؤلفون: | Machado, M.V., Policarpo, S., Coutinho, J., Carvalhana, S., Leitão, J., Carvalho, A., Silva, A.P., Velasco, F., Medeiros, I., Alves, A.C., Bourbon, M., Cortez-Pinto, H. |
| بيانات النشر: | Springer/ International Federation for the Surgery of Obesity and Metabolic Disorders |
| سنة النشر: | 2020 |
| المجموعة: | National Health Institute, Portugal: Repositório Científico |
| مصطلحات موضوعية: | Nonalcoholic Fatty Liver Disease, Obesity, Relative Fat Mass |
| الوصف: | Introduction: Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of adiposopathy. Recently, a new score was developed to estimate body fat percentage (relative fat mass, RFM). We aimed to evaluate the value of RFM in predicting the presence and severity of NAFLD, compared with other anthropometric measurements. Methods: RFM, body mass index (BMI), and other anthropometric measurements were evaluated in two cohorts of subjects: a cohort from a Portuguese prospective epidemiological study (e_Cor) and morbidly obese patients with biopsy-proven NAFLD. We evaluated if RFM and BMI were related with the presence and severity of liver disease, which was assessed by noninvasive tools in the first cohort and by liver histology in the morbidly obese cohort. The independence of relations found in univariate analysis was assessed with multivariable logistic regression analysis. Results: In the general population cohort, 744 subjects (48% male) were enrolled. BMI-defined obesity was present in 23% and RFM-defined obesity in 86%. Insulin resistance (IR) related with BMI-defined obesity (OR 4.37 [2.16-8.84]) and weight (OR 1.05 [1.02-1.08]) in men, and waist circumference (WC) (OR 1.07 [1.03-1.11]) in women. Dyslipidemia and hypertension related with RFM-defined obesity in men (OR 2.96 [1.36-6.47] and OR 5.37 [1.31-22.06], respectively). Ultrasound-diagnosed NAFLD in 33% related with weight in men (OR 1.03 [1.003-1.06] and WC in women (OR 1.06 [1.02-1.10]). In men, ALT elevation related with weight (OR 1.04 [1.02-1.07]). In women, advanced fibrosis (estimated by NAFLD Fibrosis Score) associated with BMI-defined obesity (OR 42.43 [3.61-498.13]). In the morbidly obese cohort, 152 subjects were enrolled, of whom 84% were female, 37% had steatohepatitis, and 9.4% had advanced fibrosis. Adiponectin associated inversely and leptin positively with RFM in men. The severity of steatosis increased linearly with BMI and WC in women. Higher BMI associated with steatohepatitis in women and advanced fibrosis in men. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0960-8923 |
| Relation: | https://link.springer.com/article/10.1007%2Fs11695-019-04213-8; Obes Surg. 2020 Feb;30(2):560-568. doi:10.1007/s11695-019-04213-8. Epub 2019 Oct 22; http://hdl.handle.net/10400.18/6571 |
| DOI: | 10.1007/s11695-019-04213-8 |
| الاتاحة: | http://hdl.handle.net/10400.18/6571 https://doi.org/10.1007/s11695-019-04213-8 |
| Rights: | embargoedAccess |
| رقم الانضمام: | edsbas.7CBDC4D8 |
| قاعدة البيانات: | BASE |
| تدمد: | 09608923 |
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| DOI: | 10.1007/s11695-019-04213-8 |