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Pomegranate extract augments energy expenditure counteracting the metabolic stress associated with high-fat-diet-induced obesity

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العنوان: Pomegranate extract augments energy expenditure counteracting the metabolic stress associated with high-fat-diet-induced obesity
المؤلفون: Reguero, Marina, Gómez de Cedrón, Marta, Sierra-Ramírez, Aranzazu, Fernández-Marcos, Pablo J., Reglero, Guillermo, Quintela, J. C., Ramírez de Molina, Ana
المساهمون: Comunidad de Madrid, Fundación Ramón Areces, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2022
المجموعة: Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council)
مصطلحات موضوعية: Energy expenditure, Pomegranate extract, Thermogenesis, Obesity, Meta-inflammation
الوصف: This article belongs to the Special Issue Natural Products and Obesity. ; Obesity is associated to a low grade of chronic inflammation leading to metabolic stress, insulin resistance, metabolic syndrome, dislipidemia, cardiovascular disease, and even cancer. A Mediterranean diet has been shown to reduce systemic inflammatory factors, insulin resistance, and metabolic syndrome. In this scenario, precision nutrition may provide complementary approaches to target the metabolic alterations associated to “unhealthy obesity”. In a previous work, we described a pomegranate extract (PomE) rich in punicalagines to augment markers of browning and thermogenesis in human differentiated adipocytes and to augment the oxidative respiratory capacity in human differentiated myocytes. Herein, we have conducted a preclinical study of high-fat-diet (HFD)-induced obesity where PomE augments the systemic energy expenditure (EE) contributing to a reduction in the low grade of chronic inflammation and insulin resistance associated to obesity. At the molecular level, PomE promotes browning and thermogenesis in adipose tissue, reducing inflammatory markers and augmenting the reductive potential to control the oxidative stress associated to the HFD. PomE merits further investigation as a complementary approach to alleviate obesity, reducing the low grade of chronic inflammation and metabolic stress. ; This research was funded by the Regional Government of Community of Madrid IND2017/BIO-7826; P2018/BAA-4343-ALIBIRD2020-CM), Ministerio de Ciencia e Innovación, Spain (PID2019-110183RB-C21); Ramon Areces Foundation (CIVP19A5937); EU Structural Funds and COST Action (CA17118); Synergistic Projects Community of Madrid (NUTRISION-CM/Y2020/BIO-6350); and REACT EU Program (Comunidad de Madrid and The European Regional Development Fund. ERDF. European Union-FACINGLCOVID-CM project). ; Peer reviewed
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1422-0067
Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; IND2017/BIO-7826/; P2018/BAA-4343/ALIBIRD2020-CM; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110183RB-C21/ES/DESARROLLO DE FORMULAS ALIMENTARIAS DE PRECISION DIRIGIDAS AL TRATAMIENTO DEL CANCER DE COLON: DISEÑO Y VALIDACION/; Y2020/BIO-6350/NUTRISION-CM; Publisher's version; https://doi.org/10.3390/ijms231810460; Sí; International Journal of Molecular Sciences 23(18): 10460 (2022); http://hdl.handle.net/10261/285153; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/100008054; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/100012818
DOI: 10.3390/ijms231810460
DOI: 10.13039/501100000780
DOI: 10.13039/100008054
DOI: 10.13039/501100011033
DOI: 10.13039/100012818
الاتاحة: http://hdl.handle.net/10261/285153
https://doi.org/10.3390/ijms231810460
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/100008054
https://doi.org/10.13039/501100011033
https://doi.org/10.13039/100012818
Rights: open
رقم الانضمام: edsbas.7CA269EE
قاعدة البيانات: BASE
الوصف
تدمد:14220067
DOI:10.3390/ijms231810460