Academic Journal
The Differences in Indoleamine 2,3-dioxygenase 1 Plasma Activity of HIV-Positive Pulmonary Tuberculosis and HIV-Negative Pulmonary Tuberculosis
| العنوان: | The Differences in Indoleamine 2,3-dioxygenase 1 Plasma Activity of HIV-Positive Pulmonary Tuberculosis and HIV-Negative Pulmonary Tuberculosis |
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| المؤلفون: | Kurniati, Roza, Dwitya Elvira, Rido Wandrivel |
| المصدر: | Bioscientia Medicina : Journal of Biomedicine and Translational Research; Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research ; 2634-2638 ; 2598-0580 ; 10.37275/bsm.v6i14 |
| بيانات النشر: | HM Publisher |
| سنة النشر: | 2022 |
| المجموعة: | Bioscientia Medicina - Journal of Biomedicine and Translational Research |
| مصطلحات موضوعية: | HIV, IDO1, Infection, K/T ratio, Lung tuberculosis |
| الوصف: | Background: Tuberculosis is the most common cause of death in HIV patients. Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that plays a crucial role in the immune response to TB and HIV infection. Increased plasma IDO1 activity in TB patients can be a promising marker for the diagnosis of TB, especially in HIV patients. This study aimed to evaluate the differences in the activity of indoleamine 2,3-dioxygenase 1 plasma of HIV-positive pulmonary TB with HIV-negative pulmonary TB patients. Methods: This study is an analytic observational study. Plasma IDO1 activity was assessed by calculating the kynurenine/tryptophan ratio (K/T ratio). This indicator was assessed on 28 lung TB patients divided into two groups, HIV-positive pulmonary TB and HIV-negative pulmonary TB group. Results: Twenty-eight subjects were included in this study with a mean age of 42,96 (16,17) years, with more males than females. This study's mean K/T ratio was 0.18 (0.16), with HIV-positive pulmonary TB is higher than HIV-negative pulmonary TB (0.24 vs 0.12, p = 0.027). Conclusion: There is a significant difference in the Indoleamine 2,3-dioxygenase 1 (IDO1) plasma in HIV-positive pulmonary TB and HIV-negative pulmonary TB groups. Thus the IDO1 plasma can be used as a new biomarker in diagnosed TB in HIV patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.bioscmed.com/index.php/bsm/article/view/659/841; https://www.bioscmed.com/index.php/bsm/article/view/659 |
| DOI: | 10.37275/bsm.v6i14.659 |
| الاتاحة: | https://www.bioscmed.com/index.php/bsm/article/view/659 https://doi.org/10.37275/bsm.v6i14.659 |
| رقم الانضمام: | edsbas.7C5A2FB5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.37275/bsm.v6i14.659 |
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