Academic Journal
Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center
| العنوان: | Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center |
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| المؤلفون: | Porcaro, Antonio Benito, Bianchi, Alberto, Gallina, Sebastian, Panunzio, Andrea, Tafuri, Alessandro, Serafin, Emanuele, Orlando, Rossella, Mazzucato, Giovanni, Ornaghi, Paola Irene, Cianflone, Francesco, Montanaro, Francesca, Artoni, Francesco, Baielli, Alberto, Ditonno, Francesco, Migliorini, Filippo, Brunelli, Matteo, Siracusano, Salvatore, Cerruto, Maria Angela, Antonelli, Alessandro |
| المساهمون: | Porcaro, Antonio Benito, Bianchi, Alberto, Gallina, Sebastian, Panunzio, Andrea, Tafuri, Alessandro, Serafin, Emanuele, Orlando, Rossella, Mazzucato, Giovanni, Ornaghi, Paola Irene, Cianflone, Francesco, Montanaro, Francesca, Artoni, Francesco, Baielli, Alberto, Ditonno, Francesco, Migliorini, Filippo, Brunelli, Matteo, Siracusano, Salvatore, Cerruto, Maria Angela, Antonelli, Alessandro |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | adverse pathology outcome, intermediate-risk prostate cancer, low-risk prostate cancer, progression of prostate cancer, prostate cancer, robot-assisted radical prostatectomy (RARP), tumor upgrading, tumor upstaging |
| الوصف: | Objectives: To assess the prognostic impact and predictors of adverse tumor grade in very favorable low- and intermediate-risk prostate cancer (PCa) patients treated with robot-assisted radical prostatectomy (RARP). Methods: Data of low- and intermediate PCa risk-class patients were retrieved from a prospectively maintained institutional database. Adverse tumor grade was defined as pathology ISUP grade group > 2. Disease progression was defined as a biochemical recurrence event and/or local recurrence and/or distant metastases. Associations were assessed by Cox's proportional hazards and logistic regression model. Results: Between January 2013 and October 2020, the study evaluated a population of 289 patients, including 178 low-risk cases (61.1%) and 111 intermediate-risk subjects (38.4%); unfavorable tumor grade was detected in 82 cases (28.4%). PCa progression, which occurred in 29 patients (10%), was independently predicted by adverse tumor grade and biopsy ISUP grade group 2, with the former showing stronger associations (hazard ratio, HR = 4.478; 95% CI: 1.840-10.895; p = 0.001) than the latter (HR = 2.336; 95% CI: 1.057-5.164; p = 0.036). Older age and biopsy ISUP grade group 2 were independent clinical predictors of adverse tumor grade, associated with larger tumors that eventually presented non-organ-confined disease. Conclusions: In a very favorable PCa patient population, adverse tumor grade was an unfavorable prognostic factor for disease progression. Active surveillance in very favorable intermediate-risk patients is still a hazard, so molecular and genetic testing of biopsy specimens is needed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38893256; info:eu-repo/semantics/altIdentifier/wos/WOS:001247028700001; volume:16; issue:11; firstpage:1; lastpage:14; numberofpages:14; journal:CANCERS; https://hdl.handle.net/11562/1129613; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85195685475 |
| DOI: | 10.3390/cancers16112137 |
| الاتاحة: | https://hdl.handle.net/11562/1129613 https://doi.org/10.3390/cancers16112137 |
| رقم الانضمام: | edsbas.7C3C8186 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers16112137 |
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