Academic Journal
The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions
| العنوان: | The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions |
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| المؤلفون: | Schurmans, Stéphane, Vande Catsyne, Charles-Andrew, Desmet, Christophe, Moes, Bastien |
| المصدر: | Advances in Biological Regulation (2021) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Phosphoinositides, Inositides, 5-phosphatase, INPP5K, SKIP, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, congenital muscular dystrophy, cataract, intellectual disability, insulin signaling, endoplasmic reticulum, endoplasmic reticulum stress, unfolded protein response, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | peer reviewed ; INPP5K (Inositol Polyphosphate 5-Phosphatase K, or SKIP (for Skeletal muscle and Kidney enriched Inositol Phosphatase) is a member of the phosphoinositide 5-phosphatases family. Its protein structure is comprised of a N-terminal catalytic domain which hydrolyses both PtdIns(4,5)P2 and PtdIns(3,4,5)P3, followed by a SKICH domain at the C-terminus which is responsible for protein-protein interactions and subcellular localization of INPP5K. Strikingly, INPP5K is mostly concentrated in the endoplasmic reticulum, although it is also detected at the plasma membrane, in the cytosol and the nucleus. Recently, mutations in INPP5K have been detected in patients with a rare form of autosomal recessive congenital muscular dystrophy with cataract, short stature and intellectual disability. INPP5K functions extend from control of insulin signaling, endoplasmic reticulum stress response and structural integrity, myoblast differentiation, cytoskeleton organization, cell adhesion and migration, renal osmoregulation, to cancer. The goal of this review is thus to summarize and comment recent and less recent data in the literature on INPP5K, in particular on the structure, expression, intracellular localization, interactions and functions of this specific member of the 5-phosphatases family. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2212-4926 2212-4934 |
| Relation: | urn:issn:2212-4926; urn:issn:2212-4934; https://orbi.uliege.be/handle/2268/250960; info:hdl:2268/250960; https://orbi.uliege.be/bitstream/2268/250960/1/Merged%20Review%20INPP5K%202020.pdf; info:pmid:33060052 |
| DOI: | 10.1016/j.jbior.2020.100760 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/250960 https://orbi.uliege.be/bitstream/2268/250960/1/Merged%20Review%20INPP5K%202020.pdf https://doi.org/10.1016/j.jbior.2020.100760 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7C2E64F5 |
| قاعدة البيانات: | BASE |
| تدمد: | 22124926 22124934 |
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| DOI: | 10.1016/j.jbior.2020.100760 |