Academic Journal
Osteocalcin: A new phenomenon for type 2 diabetes and obesity
| العنوان: | Osteocalcin: A new phenomenon for type 2 diabetes and obesity |
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| المؤلفون: | Tek, Nilüfer, Kocak, Tevfik |
| سنة النشر: | 2023 |
| الوصف: | Objectives: The molecular biology revolution has emerged with the determination that bone tissue is anendocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derivedprotein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. Bycontrolling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulinexpression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acidoxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recentresearch suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gammacoactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brownadipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue.OCN the target gene of insulin, and resting energy expenditure and mitochondrial biogenesis. With all theseeffects, OCN is a protein that has recently been found to be associated with diabetes and obesity components.Conclusions: This review aims to present an overview of understanding the interaction of OCN produced byosteoblasts with insulin, glucose metabolism, adipose tissue, skeletal and muscle tissue, and appetite metabolismin understanding the endocrine functions of bone. In addition, it was conducted to examine the role of OCN inenergy metabolism and to evaluate the relationship of energy metabolism pathways affected by OCN with noncommunicable chronic diseases such as type 2 diabetes mellitus and obesity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | a04dc783-bbf1-404c-871d-4ec99644d22c; https://avesis.gazi.edu.tr/publication/details/a04dc783-bbf1-404c-871d-4ec99644d22c/oai |
| DOI: | 10.29333/ejeph/12799 |
| الاتاحة: | https://doi.org/10.29333/ejeph/12799 https://avesis.gazi.edu.tr/publication/details/a04dc783-bbf1-404c-871d-4ec99644d22c/oai |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7C2C2A6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.29333/ejeph/12799 |
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