Academic Journal
Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs
| العنوان: | Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs |
|---|---|
| المؤلفون: | Dahm, Sophia I., Kenna, Kelly R., Stewart, David, Pereira-Fantini, Prue M., McCall, Karen E., Perkins, Elizabeth J, Sourial, Magdy, Tingay, David G. |
| المصدر: | Pediatric Research ; volume 93, issue 5, page 1226-1232 ; ISSN 0031-3998 1530-0447 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Background The impact of different respiratory strategies at birth on the preterm lung is well understood; however, concerns have been raised that lung recruitment may impede cerebral haemodynamics. This study aims to examine the effect of three different ventilation strategies on carotid blood flow, carotid artery oxygen content and carotid oxygen delivery. Methods 124–127-day gestation apnoeic intubated preterm lambs studied as part of a larger programme primarily assessing lung injury were randomised to positive pressure ventilation with positive end-expiratory pressure (PEEP) 8 cmH 2 O (No-RM; n = 12), sustained inflation (SI; n = 15) or dynamic PEEP strategy (DynPEEP; maximum PEEP 14 or 20 cmH 2 O, n = 41) at birth, followed by 90 min of standardised ventilation. Haemodynamic data were continuously recorded, with intermittent arterial blood gas analysis. Results Overall carotid blood flow measures were comparable between strategies. Except for mean carotid blood flow that was significantly lower for the SI group compared to the No-RM and DynPEEP groups over the first 3 min ( p < 0.0001, mixed effects model). Carotid oxygen content and oxygen delivery were similar between strategies. Maximum PEEP level did not alter cerebral haemodynamic measures. Conclusions Although there were some short-term variations in cerebral haemodynamics between different PEEP strategies and SI, these were not sustained. Impact Different pressure strategies to facilitate lung aeration at birth in preterm infants have been proposed. There is minimal information on the effect of lung recruitment on cerebral haemodynamics. This is the first study that compares the effect of sustained lung inflation and dynamic and static positive end-expiratory pressure on cerebral haemodynamics. We found that the different ventilation strategies did not alter carotid blood flow, carotid oxygen content or carotid oxygen delivery. This preclinical study provides some reassurance that respiratory strategies designed to focus on lung aeration ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41390-022-02244-z |
| الاتاحة: | http://dx.doi.org/10.1038/s41390-022-02244-z https://www.nature.com/articles/s41390-022-02244-z.pdf https://www.nature.com/articles/s41390-022-02244-z |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.7BAE48 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41390-022-02244-z |
|---|