Academic Journal
Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs
| العنوان: | Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs |
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| المؤلفون: | Nixon, Victoria, L, Mcdougall, Alex, Jones, Keith, T |
| المساهمون: | Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0248-4900. |
| بيانات النشر: | CCSD Wiley |
| سنة النشر: | 2000 |
| المجموعة: | Institut national des sciences de l'Univers: HAL-INSU |
| مصطلحات موضوعية: | [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | International audience ; At fertilisation of mammalian and ascidian eggs the sperm induces a series of Ca 2+ oscillations. These Ca 2+ oscillations are triggered by a sperm-borne Ca 2+-releasing factor whose identity is still unresolved. In both mammals and ascidians Ca 2+ oscillations in eggs are associated with the period leading up to exit from meiosis and entry into the first embryonic cell cycle. Thus, in mammals Ca 2+ oscillations continue for several hours but are complete by within 30 min in the ascidian. In mammals and ascidians Ca 2+ oscillations stop at around the time when pronuclei form in the 1-cell embryo. There is evidence to show that cell cycle factors are important in regulating the fertilisation Ca 2+ signal. If the formation of pronuclei is blocked either in mammals (by spindle disruption) or in ascidians (by clamping maturation promoting factor levels high) then Ca 2+ oscillations continue indefinitely. Here, we explore the nature of the sperm Ca 2+-releasing factor and examine the relationship between cell cycle resumption and the control of Ca 2+ oscillations at fertilisation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/s0248-4900(00)01068-6 |
| الاتاحة: | https://hal.science/hal-03025745 https://hal.science/hal-03025745v1/document https://hal.science/hal-03025745v1/file/2000%20NixonBiolCell2000.pdf https://doi.org/10.1016/s0248-4900(00)01068-6 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7BA333A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/s0248-4900(00)01068-6 |
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