Academic Journal
Listeria monocytogenes pathogenesis : the role of stress adaptation
| العنوان: | Listeria monocytogenes pathogenesis : the role of stress adaptation |
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| المؤلفون: | Sibanda, Thulani, Buys, E.M. (Elna Maria) |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | University of Pretoria: UPSpace |
| مصطلحات موضوعية: | Listeria monocytogenes, Virulence, Stress response, Sigma factor B (SigB), Positive regulatory factor A (PrfA), Gastrointestinal tract (GIT), SDG-02: Zero hunger |
| الوصف: | Adaptive stress tolerance responses are the driving force behind the survival ability of Listeria monocytogenes in different environmental niches, within foods, and ultimately, the ability to cause human infections. Although the bacterial stress adaptive responses are primarily a necessity for survival in foods and the environment, some aspects of the stress responses are linked to bacterial pathogenesis. Food stress-induced adaptive tolerance responses to acid and osmotic stresses can protect the pathogen against similar stresses in the gastrointestinal tract (GIT) and, thus, directly aid its virulence potential. Moreover, once in the GIT, the reprogramming of gene expression from the stress survival-related genes to virulence-related genes allows L. monocytogenes to switch from an avirulent to a virulent state. This transition is controlled by two overlapping and interlinked transcriptional networks for general stress response (regulated by Sigma factor B, (SigB)) and virulence (regulated by the positive regulatory factor A (PrfA)). This review explores the current knowledge on the molecular basis of the connection between stress tolerance responses and the pathogenesis of L. monocytogenes. The review gives a detailed background on the currently known mechanisms of pathogenesis and stress adaptation. Furthermore, the paper looks at the current literature and theories on the overlaps and connections between the regulatory networks for SigB and PrfA. ; https://www.mdpi.com/journal/microorganisms ; am2023 ; Consumer Science |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | 2076-2607 (online); http://hdl.handle.net/2263/92361 |
| DOI: | 10.3390/microorganisms10081522 |
| الاتاحة: | http://hdl.handle.net/2263/92361 https://doi.org/10.3390/microorganisms10081522 |
| Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. |
| رقم الانضمام: | edsbas.7B90C0F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms10081522 |
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