Academic Journal
Applications of coarse-grained models in metabolic engineering
| العنوان: | Applications of coarse-grained models in metabolic engineering |
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| المؤلفون: | Doan, Dieu Thi, Hoang, Manh Dat, Heins, Anna-Lena, Kremling, Andreas |
| سنة النشر: | 2022 |
| المجموعة: | Hamburg University of Technology (TUHH): TUBdok |
| مصطلحات موضوعية: | kinetic model, mathematical modeling, metabolic and gene regulatory networks, metabolic engineering, microbial growth, resource allocation, systems biotechnology, 624: Civil Engineering, Environmental Engineering |
| الوصف: | Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-889X |
| Relation: | Frontiers in Molecular Biosciences; Frontiers in Molecular Biosciences 9: 1-14 (2023-03-08); https://hdl.handle.net/11420/42577; 2-s2.0-85127368632 |
| DOI: | 10.15480/882.8136 |
| الاتاحة: | https://hdl.handle.net/11420/42577 https://doi.org/10.15480/882.8136 |
| Rights: | true ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.7B4DEF4B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296889X |
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| DOI: | 10.15480/882.8136 |