Academic Journal
Galectin-3 in Heart Failure:An Update of the Last 3 Years
| العنوان: | Galectin-3 in Heart Failure:An Update of the Last 3 Years |
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| المؤلفون: | Gehlken, Carolin, Suthahar, Navin, Meijers, Wouter C., de Boer, Rudolf A. |
| المصدر: | Gehlken , C , Suthahar , N , Meijers , W C & de Boer , R A 2018 , ' Galectin-3 in Heart Failure : An Update of the Last 3 Years ' , Heart failure clinics , vol. 14 , no. 1 , pp. 75-92 . https://doi.org/10.1016/j.hfc.2017.08.009 |
| سنة النشر: | 2018 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Galectin-3, Heart failure, Fibrosis, Galectin-3 inhibitor, Biomarker, Prognosis, PRESERVED EJECTION FRACTION, MODIFIED CITRUS PECTIN, PROGNOSTIC VALUE, CARDIOVASCULAR-DISEASE, MYOCARDIAL FIBROSIS, RISK STRATIFICATION, GENERAL-POPULATION, PREDICTIVE-VALUE, PERFORMANCE-CHARACTERISTICS, SERIAL MEASUREMENTS |
| الوصف: | Galectin-3 plays a role in tissue inflammation, repair, and fibrosis. This article specifically focuses on heart failure (HF), in which galectin-3 has been shown to be a useful biomarker in prognosis and risk stratification, especially in HF with preserved ejection fraction. Experimental research has shown that galectin-3 directly induces pathologic remodeling of the heart, and is therefore considered a culprit protein in the development of cardiac fibrosis in HF, with potentially relevant clinical implications. In summary, galectin-3 is a biomarker and biotarget in cardiac remodeling and fibrosis and future research will target galectin-3-centered diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.hfc.2017.08.009 |
| الاتاحة: | https://hdl.handle.net/11370/4e4b8c99-8f60-422a-9278-5bafb7616514 https://research.rug.nl/en/publications/4e4b8c99-8f60-422a-9278-5bafb7616514 https://doi.org/10.1016/j.hfc.2017.08.009 https://pure.rug.nl/ws/files/499291270/Galectin_3_in_Heart_Failure_Elsevier_Enhanced_Reader.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7B264529 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.hfc.2017.08.009 |
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