Academic Journal
Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations
| العنوان: | Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations |
|---|---|
| المؤلفون: | Vidal-Jordana, Angela, Sastre-Garriga, Jaume, Pareto, Deborah, Tur, Carmen, Arrambide, Georgina, Otero-Romero, Susana, Huerga, Elena, Mitjana, Raquel, Auger, Cristina, Tintoré, Mar, Rovira, Alex, Montalban, Xavier |
| المصدر: | Multiple Sclerosis Journal ; volume 24, issue 6, page 721-727 ; ISSN 1352-4585 1477-0970 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2017 |
| الوصف: | Background: Brain atrophy in multiple sclerosis (MS) patients is present since the very early stages of the disease and it has been related to long-term disability. Objective: To estimate brain volume (BV) at 15 years after a clinically isolated syndrome (CIS) and to evaluate its relationship with disease outcomes. Methods: From a prospective cohort including patients presenting with a CIS, 54 patients with a brain magnetic resonance imaging (MRI) performed 15 years after CIS were included. Brain parenchymal fraction (BPF), grey matter fraction (GMF) and white matter fraction (WMF) at 15-year follow-up were obtained. Regression analyses were conducted to predict BV loss and reaching an Expanded Disability Status Scale (EDSS) of 3.0 in that 15-year period. Results: In multivariable analyses, lower values of BPF and WMF were significantly associated with being male, presenting 3–4 Barkhof criteria at baseline, presenting a second relapse, and with a decision to start treatment. In the multivariable logistic regression analysis, only lower GMF was associated with a greater risk of reaching EDSS 3.0 (odds ratio (OR) = 0.24, p = 0.028). Conclusion: Lower BPF and WMF 15 years after CIS are associated with previous markers of inflammatory disease. Lower GMF 15 years after a CIS is associated with an increased risk of reaching an EDSS of 3.0. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1352458517707070 |
| الاتاحة: | https://doi.org/10.1177/1352458517707070 https://journals.sagepub.com/doi/pdf/10.1177/1352458517707070 https://journals.sagepub.com/doi/full-xml/10.1177/1352458517707070 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.7AF592CC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1352458517707070 |
|---|