Academic Journal
The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans
| العنوان: | The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans |
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| المؤلفون: | Romani, Luigina, Montagnoli, Claudia, Bozza, Silvia, Perruccio, Katia, Spreca, Antonio, Allavena, Paola, Verbeek, Sjef, Calderone, Richard A., Bistoni, Francesco, Puccetti, Paolo |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2004 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ORIGINAL RESEARCH PAPERS |
| الوصف: | Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T h cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fcγ receptors was responsible for suppression of mannose receptor‐dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://intimm.oxfordjournals.org/cgi/content/short/16/1/149; http://dx.doi.org/10.1093/intimm/dxh012 |
| DOI: | 10.1093/intimm/dxh012 |
| الاتاحة: | http://intimm.oxfordjournals.org/cgi/content/short/16/1/149 https://doi.org/10.1093/intimm/dxh012 |
| Rights: | Copyright (C) 2004, The Japanese Society for Immunology |
| رقم الانضمام: | edsbas.7AEBDE49 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/intimm/dxh012 |
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