Academic Journal
Atypical location of cannabinoid receptors in white matter areas during rat brain development. Synapse 26:317–323
| العنوان: | Atypical location of cannabinoid receptors in white matter areas during rat brain development. Synapse 26:317–323 |
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| المؤلفون: | J. Romero, E. Garcia-palomero, F. Berrendero, L. Garcia-gil, M. L. Hernandez, J. A. Ramos, J. J. Fernandez-ruiz |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.druglibrary.org/crl/receptors/receptors/Romero et.al 97 Development_ Synapse.pdf. |
| سنة النشر: | 1997 |
| المجموعة: | CiteSeerX |
| الوصف: | KEY WORDS cannabinoid receptors; prenatal and early postnatal ontogeny; brain development; autoradiography ABSTRACT Previous evidence suggests that the endogenous cannabinoid system could emerge and be operative early during brain development. In the present study, we have explored the distribution of specific binding for cannabinoid receptors in rat brain at gestational day 21 (GD21), postnatal days 5 (PND5) and 30 (PND30), and at adult age (.70 days after birth) by using autoradiography with [3H]CP-55,940. Our results indicated that specific binding for cannabinoid receptors can be detected in the brain of rat fetuses at GD21 in the classic areas that contain these receptors in adulthood—in particular, in the cerebellum and the hippocampus and, to a lesser extent, in the basal ganglia, several limbic structures, and cerebral cortex. The density of cannabinoid receptors in all these structures increased progressively at all postnatal ages studied until reaching the classical adult values in 70-day-old animals. Interestingly, cannabi-noid receptor binding can also be detected at GD21 in regions, in which they are scarcely distributed or not located in the adult brain and that have the particularity of all being |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.534.3235; http://www.druglibrary.org/crl/receptors/receptors/Romero et.al 97 Development_ Synapse.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.534.3235 http://www.druglibrary.org/crl/receptors/receptors/Romero et.al 97 Development_ Synapse.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.7AB62C5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |