Academic Journal
INFLUENCE OF ACUTE BLOOD LOSS COMPLICATED BY LIMB ISCHEMIA-REPERFUSION ON THE ACTIVITY OF LIPID PEROXIDATION PROCESSES IN LUNGS AND THEIR CORRECTION WITH CARBACETAM ; ВПЛИВ ГОСТРОЇ КРОВОВТРАТИ, УСКЛАДНЕНОЇ ІШЕМІЄЮ-РЕПЕРФУЗІЄЮ КІНЦІВКИ, НА АКТИВНІСТЬ ПРОЦЕСІВ ЛІПІДНОЇ ПЕРОКСИДАЦІЇ У ЛЕГЕНЯХ ТА ЇХ КОРЕКЦІЯ КАРБАЦЕТАМОМ
| العنوان: | INFLUENCE OF ACUTE BLOOD LOSS COMPLICATED BY LIMB ISCHEMIA-REPERFUSION ON THE ACTIVITY OF LIPID PEROXIDATION PROCESSES IN LUNGS AND THEIR CORRECTION WITH CARBACETAM ; ВПЛИВ ГОСТРОЇ КРОВОВТРАТИ, УСКЛАДНЕНОЇ ІШЕМІЄЮ-РЕПЕРФУЗІЄЮ КІНЦІВКИ, НА АКТИВНІСТЬ ПРОЦЕСІВ ЛІПІДНОЇ ПЕРОКСИДАЦІЇ У ЛЕГЕНЯХ ТА ЇХ КОРЕКЦІЯ КАРБАЦЕТАМОМ |
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| المؤلفون: | Stakhiv, O. V., Maksymyv, R. V. |
| المصدر: | Bulletin of Medical and Biological Research; No. 3 (2020): Bulletin of Medical and Biological Research; 108-114 ; Вісник медичних і біологічних досліджень; № 3 (2020): Вісник медичних і біологічних досліджень; 108-114 ; 2706-6290 ; 2706-6282 ; 10.11603/bmbr.2706-6290.2020.3 |
| بيانات النشر: | Ternopil National Medical University |
| سنة النشر: | 2020 |
| المجموعة: | Scientific Journals of Ternopil State Medical University / Наукові журнали Тернопільського державного медичного університету імені І.Я.Горбачевського |
| مصطلحات موضوعية: | гостра крововтрата, ішемія-реперфузія кінцівки, реагенти до тіобарбітурової кислоти, легені, карбацетам, acute blood loss, ischemia-reperfusion of the limb, reagents for thiobarbituric acid, lungs, carbocetam |
| الوصف: | Summary. Recently, there has been a significant increase in the frequency of terrorist attacks and local armed conflicts. Their characteristic feature was an increase in the number of wounded with massive external bleeding, which require immediate use of a tourniquet with the maximum safe period of complete ischemia of the limb up to 2 hours. It is proved that ischemia of the limb and acute blood loss contribute to the initiation of lipid peroxidation due to increased production of reactive oxygen species. The aim of the study – to determine the effect of acute blood loss complicated by limb ischemia-reperfusion on the intensity of lipid peroxidation of the lungs and the effectiveness of correction of detected disorders by carbacetam. Materials and Methods. The study was performed on 216 white nonlinear male rats weighing 200–220 g. All experiments were performed under thiopental-sodium anesthesia. In animals, limb ischemia-reperfusion and acute blood loss were simulated and these lesions were combined. In a separate group, the detected disorders were corrected with carbacetam. After 1 and 2 hours, as well as after 1, 7 and 14 days in experimental animals, the content of reagents to thiobarbituric acid was determined, which belongs to the screening indicators of the activity of lipid peroxidation processes. Results. Under conditions of ischemia-reperfusion of the limb, acute blood loss and their combination in the lungs increases the content of reagents to thiobarbituric acid. If after modeling only ischemia-reperfusion of the limb the figure is normalized up to 14 days, then after modeling acute blood loss and its complication by ischemia-reperfusion of the limb, the figure increases with the first maximum after 1 day and the second after 14 days and significantly exceeds the control level. Complications of acute blood loss by ischemia-reperfusion of the limb at all times is accompanied by a higher content of reagents to thiobarbituric acid compared to other experimental groups, which suggests a mutual burden ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | https://ojs.tdmu.edu.ua/index.php/bmbr/article/view/11525/10939; https://ojs.tdmu.edu.ua/index.php/bmbr/article/view/11525 |
| DOI: | 10.11603/bmbr.2706-6290.2020.3.11525 |
| الاتاحة: | https://ojs.tdmu.edu.ua/index.php/bmbr/article/view/11525 https://doi.org/10.11603/bmbr.2706-6290.2020.3.11525 |
| رقم الانضمام: | edsbas.7AADC194 |
| قاعدة البيانات: | BASE |
| DOI: | 10.11603/bmbr.2706-6290.2020.3.11525 |
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