Academic Journal
Effect of low molecular weight heparin on bone metabolism and hyperlipidemia in patients on maintenance hemodialysis
| العنوان: | Effect of low molecular weight heparin on bone metabolism and hyperlipidemia in patients on maintenance hemodialysis |
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| المؤلفون: | Lai, KN, Tong, MKL, Fung, KS, Lam, CWK, Ho, K, Cheung, RCK, Lit, LCW, Lee, SKM |
| بيانات النشر: | //www.artificial-organs.com Italy |
| سنة النشر: | 2001 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Low molecular weight heparin, Osteoporosis, Unfractionated heparin, Hemodialysis, Hyperlipidemia |
| الوصف: | The effect of low molecular weight heparin (LMWH) on serum lipid profile in hemodialysis remains controversial and its effect on bone metabolism has not been studied. A crossover study was conducted in 40 patients on stable hemodialysis using unfractionated heparin (UFH) for more than 24 months. These patients were then treated with a LMWH (nadroparin-Ca) for 8 months during hemodialysis and subsequently switched back to UFH for 12 months. Serum lipid profile, biochemical markers for bone metabolism, and bone densitometry (BMD) were monitored at four-month intervals while all medications remained unchanged. Cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), lipoprotein(a) (Lp(a)), apolipoprotein B (Apo B) were raised in 35%, 29%, 12%, 24% and 24% of patients respectively. High-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A1 (Apo A-1) were reduced in 47% and 9% of patients. Bone-specific alkaline phosphatase (BALP) and intact osteocalcin (OSC), both reflecting osteoblastic activity, were raised in 65% and 94% of patients. Tartrate-resistant acid phosphatase (TRACP) reflecting osteoclastic activity and parathyroid hormone (PTH) were elevated in 35% and 88% of patients. Following LMWH treatment, TC, Tg, Lp(a) and Apo B were reduced by 7%, 30%, 21% and 10% respectively (p<0.05 or <0.01) while Apo A-1 were raised by 7% (p<0.01). Simultaneously, TRACP was reduced by 13% (p<0.05). These biochemical changes were detected soon after 4 months of LMWH administration. Although BMD values in our patients were lower than those of age-matched normal subjects, significant changes were not observed with LMWH treatment. After switching back to UFH for hemodialysis, these biochemical indices reverted to previous values during UFH treatment with a significant higher level in TC and Apo B while serum Apo A-1 remained elevated. Our study suggests LMWH may partially alleviate hyperlipidemia and, perhaps, osteoporosis associated with UFH administration in patients on maintenance ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0391-3988 |
| Relation: | International Journal of Artificial Organs; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034788031&selection=ref&src=s&origin=recordpage; International Journal Of Artificial Organs, 2001, v. 24 n. 7, p. 447-455; 455; 69575; WOS:000170248900005; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0391-3988&volume=24&spage=447&epage=455&date=2001&atitle=Effect+of+low+molecular+weight+heparin+on+bone+metabolism+and+hyperlipidemia+in+patients+on+maintenance+hemodialysis; eid_2-s2.0-0034788031; 447; http://hdl.handle.net/10722/76562; 24 |
| الاتاحة: | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0391-3988&volume=24&spage=447&epage=455&date=2001&atitle=Effect+of+low+molecular+weight+heparin+on+bone+metabolism+and+hyperlipidemia+in+patients+on+maintenance+hemodialysis http://hdl.handle.net/10722/76562 |
| رقم الانضمام: | edsbas.7A9C6506 |
| قاعدة البيانات: | BASE |
| تدمد: | 03913988 |
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