Academic Journal
Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia
| العنوان: | Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia |
|---|---|
| المؤلفون: | Reijnders, Tom D Y, Laterre, Pierre-François, François, Bruno, Sánchez García, Miguel, van Engelen, Tjitske S R, Sie, Daoud, Scicluna, Brendon P, Ostanin, Dmitry V, Galinsky, Kevin J, Butler, Joe M, Lombardo, Eleuterio, van der Poll, Tom |
| المساهمون: | Research and Innovation Program, NWO |
| المصدر: | Thorax ; volume 79, issue 11, page 1086-1090 ; ISSN 0040-6376 1468-3296 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2024 |
| الوصف: | Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/thorax-2024-222026 |
| الاتاحة: | http://dx.doi.org/10.1136/thorax-2024-222026 https://syndication.highwire.org/content/doi/10.1136/thorax-2024-222026 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.7A9B0C41 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/thorax-2024-222026 |
|---|