Academic Journal
Structure-activity relationships of indole- and pyrrole-derived cannabinoids’, The
| العنوان: | Structure-activity relationships of indole- and pyrrole-derived cannabinoids’, The |
|---|---|
| المؤلفون: | Jenny L. Wiley, David R. Compton, Dong Dai, Julia A. H. Lainton, Michelle Phillips, John W. Huffman, Billy R. Martin |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.druglibrary.org/crl/receptors/agonists/Wiley et.al 98 Structure Activity JPharmacoExpTher.pdf. |
| سنة النشر: | 1998 |
| المجموعة: | CiteSeerX |
| الوصف: | Early molecular modeling studies with D9-tetrahydrocannabinol (D9-THC) reported that three discrete regions which interact with brain cannabinoid (CB1) receptors corresponded to the C-9 position of the cyclohexene ring, the phenolic hydroxyl and the carbon side chain at the C3 position. Although the location of these attachment points for aminoalkylindoles is less clear, the naphthalene ring, the carbonyl group and the morpholin-oethyl group have been suggested as probable sites. In this study, a series of indole- and pyrrole-derived cannabinoids was developed, in which the morpholinoethyl group was replaced with another cyclic structure or with a carbon chain that more directly corresponded to the side chain of D9-THC and were tested for CB1 binding affinity and in a battery of in vivo tests, including hypomobility, antinociception, hypothermia and cat- |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.582.9403; http://www.druglibrary.org/crl/receptors/agonists/Wiley et.al 98 Structure Activity JPharmacoExpTher.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.582.9403 http://www.druglibrary.org/crl/receptors/agonists/Wiley et.al 98 Structure Activity JPharmacoExpTher.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.7A8BBF02 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |