التفاصيل البيبلوغرافية
| العنوان: |
Physiological Aspects of Rat Activity, Their Anxiety and Memory After Administration of Full Gabaa-receptor Complex Agonist Propoxazepam |
| المؤلفون: |
Golovenko, M. (Mykola), Belenichev, I. (Igor), Larionov, V. (Vitalii), Reder, A. (Anatoliy), Serhiy, A. (Andronati) |
| المصدر: |
ScienceRise: Biological Science |
| بيانات النشر: |
PC TECHNOLOGY CENTER |
| سنة النشر: |
2020 |
| المجموعة: |
neliti (Indonesia's Think Tank Database) |
| مصطلحات موضوعية: |
propoxazepam, locomotor and exploratory activity, reference and working memory, УДК 615.213'453.6.015, пропоксазепам, рухова і пошукова активність, референтна і робоча пам’ять, двигательная и поисковая активность, референтная и рабочая память, Indonesia |
| الوصف: |
The action of 7-bromo-5 (o-chlorophenyl) -3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one (propoxazepam) with prolonged administration in various doses on behavioural reactions, anxiety and the memory of rats, as well as their muscle tone was estimated, which is important paying attention to its main (anticonvulsant and analgesic) pharmacological effects.The aim of the study was a comparative assessment of the severity and duration of propoxazepam effect after its administration to rats at doses of 2, 5 and 10 mg/kg (10 days) on higher functions of the central nervous system according to indicators such as motor and exploratory activity, as well as reference and working memory .Materials and methods. The study was conducted on 40 Wistar rats weighing 220-290 g. The psychophysiological state of the animals was evaluated using the "open field" test, the formation of spatial working and long-term memory in a radial eight-arm maze, muscle relaxation, imbalance and movements coordination - using the "rotating rod" method. Statistical processing was performed in Microsoft Excel 2016 with AtteStat 12.The results of the study. When comparing the test results of the "open field", "radial labyrinth" and "rotarod" in groups of animals that were administered different doses of the compound, it was found that, in general, these parameters at doses of 2 mg/kg and 5 mg/kg statistically significantly different (increase) from control values, but are similar. At a dose of 10 mg/kg, most of the parameters (except for the rotarod test) for these animals were characterized by a downward trend.Conclusions. The administration of the drug in doses of 2, 5 and 10 mg/kg leads to a decrease in anxious behaviour of animals, which is also accompanied by a pronounced dose-dependent negative effect on the endurance, coordination and memory of animals. The administration of the drug at a dose of 10 mg/kg impaired the learning ability of animals and reduced memory function. This should be considered in clinical studies of the compound |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Indonesian |
| Relation: |
https://www.neliti.com/publications/527387/physiological-aspects-of-rat-activity-their-anxiety-and-memory-after-administrat |
| الاتاحة: |
https://www.neliti.com/publications/527387/physiological-aspects-of-rat-activity-their-anxiety-and-memory-after-administrat |
| Rights: |
(c) ScienceRise: Biological Science, 2020 |
| رقم الانضمام: |
edsbas.7A53A06E |
| قاعدة البيانات: |
BASE |