Academic Journal
Ruthenium-catalyzed reductive arylation of N‐(2‐Pyridinyl)amides with isopropanol and arylboronate esters
| العنوان: | Ruthenium-catalyzed reductive arylation of N‐(2‐Pyridinyl)amides with isopropanol and arylboronate esters |
|---|---|
| المؤلفون: | Ronson, Thomas O., Renders, Evelien, Van Steijvoort, Ben, Wang, Xubin, Wybon, Clarence, Prokopcová, Hana, Meerpoel, Lieven, Maes, Bert |
| المصدر: | 1433-7851 ; Angewandte Chemie: international edition in English |
| سنة النشر: | 2019 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Chemistry |
| الوصف: | A new three‐component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2‐pyridinyl (Py) directing group, is described. The N‐Py‐amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N‐Py‐1‐arylalkanamine reaction products easily transformed into the corresponding chlorides by substitution of the HN‐Py group with HCl. The 1‐aryl‐1‐chloroalkane products allow substitution and cross‐coupling reactions; thereby, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py‐NH2 by‐product can be recycled. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isi/000454944900016 |
| الاتاحة: | https://hdl.handle.net/10067/1545990151162165141 https://repository.uantwerpen.be/docman/irua/d3246b/154599_2019_11_01.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7A24EB9C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |