Academic Journal
Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells
| العنوان: | Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells |
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| المؤلفون: | Elsley William, Quartey-Papafio Ruby, Page Mark, Hall Joanna, Smith Deborah, Ferguson Deborah, Ham Claire, Berry Neil, Li Bo, Robinson Mark, Almond Neil, Stebbings Richard |
| المصدر: | Retrovirology, Vol 8, Iss 1, p 8 (2011) |
| بيانات النشر: | BMC |
| سنة النشر: | 2011 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Background Vaccination with live attenuated SIV can protect against detectable infection with wild-type virus. We have investigated whether target cell depletion contributes to the protection observed. Following vaccination with live attenuated SIV the frequency of intestinal CD4+CCR5+ T cells, an early target of wild-type SIV infection and destruction, was determined at days 3, 7, 10, 21 and 125 post inoculation. Results In naive controls, modest frequencies of intestinal CD4+CCR5+ T cells were predominantly found within the LPL T TrM-1 and IEL T TrM-2 subsets. At day 3, LPL and IEL CD4+CCR5+ T EM cells were dramatically increased whilst less differentiated subsets were greatly reduced, consistent with activation-induced maturation. CCR5 expression remained high at day 7, although there was a shift in subset balance from CD4+CCR5+ T EM to less differentiated T TrM-2 cells. This increase in intestinal CD4+CCR5+ T cells preceded the peak of SIV RNA plasma loads measured at day 10. Greater than 65.9% depletion of intestinal CD4+CCR5+ T cells followed at day 10, but overall CD4+ T cell homeostasis was maintained by increased CD4+CCR5- T cells. At days 21 and 125, high numbers of intestinal CD4+CCR5- naive T N cells were detected concurrent with greatly increased CD4+CCR5+ LPL T TrM-2 and IEL T EM cells at day 125, yet SIV RNA plasma loads remained low. Conclusions This increase in intestinal CD4+CCR5+ T cells, following vaccination with live attenuated SIV, does not correlate with target cell depletion as a mechanism of protection. Instead, increased intestinal CD4+CCR5+ T cells may correlate with or contribute to the protection conferred by vaccination with live attenuated SIV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1742-4690 |
| Relation: | http://www.retrovirology.com/content/8/1/8; https://doaj.org/toc/1742-4690; https://doaj.org/article/feed2c17b99f4e6884ac48ee5d2f7238 |
| DOI: | 10.1186/1742-4690-8-8 |
| الاتاحة: | https://doi.org/10.1186/1742-4690-8-8 https://doaj.org/article/feed2c17b99f4e6884ac48ee5d2f7238 |
| رقم الانضمام: | edsbas.79E6BAE8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17424690 |
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| DOI: | 10.1186/1742-4690-8-8 |