Academic Journal
Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis
| العنوان: | Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis |
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| المؤلفون: | Feldman, Peter R., Gentile, Pietro, Piwko, Charles, Motswaledi, Hendrik M., Gorun, Samantha, Pesachov, Jacob, Markel, Michael, Silver, Maxwell I., Brenkel, Megan, Feldman, Oriel J., Kamen, Corey L., Uleryk, Elizabeth, Guevara-Aguirre, Jaime, Fiebig, Klaus M. |
| المساهمون: | Government of Canada |
| المصدر: | Frontiers in Medicine ; volume 9 ; ISSN 2296-858X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background Androgenetic alopecia (AGA) affects almost half the population, and several treatments intending to regenerate a normal scalp hair phenotype are used. This is the first study comparing treatment efficacy response and resistance using standardized continuous outcomes. Objective To systematically compare the relative efficacy of treatments used for terminal hair (TH) regrowth in women and men with AGA. Methods A systematic literature review was conducted (from inception to August 11, 2021) to identify randomized, Placebo-controlled trials with ≥ 20 patients and reporting changes in TH density after 24 weeks. Efficacy was analyzed by sex at 12 and 24 weeks using Bayesian network meta-analysis (B-NMA) and compared to frequentist and continuous outcomes profiles. Results The search identified 2,314 unique articles. Ninety-eight were included for full-text review, and 17 articles met the inclusion criteria for data extraction and analyses. Eligible treatments included ALRV5XR, Dutasteride 0.5 mg/day, Finasteride 1 mg/day, low-level laser comb treatment (LLLT), Minoxidil 2% and 5%, Nutrafol, and Viviscal. At 24 weeks, the B-NMA regrowth efficacy in TH/cm 2 and significance ( ** ) in women were ALRV5XR: 30.09 ** , LLLT: 16.62 ** , Minoxidil 2%: 12.13 ** , Minoxidil 5%: 10.82 ** , and Nutrafol: 7.32 ** , and in men; ALRV5XR: 21.03 ** , LLLT: 18.75 ** , Dutasteride: 18.37 ** , Viviscal: 13.23, Minoxidil 5%: 13.13 ** , Finasteride: 12.38, and Minoxidil 2%: 10.54. Two distinct TH regrowth response profiles were found; Continuous: ALRV5XR regrowth rates were linear in men and accelerated in women; Resistant: after 12 weeks, LLLT, Nutrafol, and Viviscal regrowth rates attenuated while Dutasteride and Finasteride plateaued; Minoxidil 2% and 5% lost some regrowth. There were no statistical differences for the same treatment between women and men. B-NMA provided more accurate, statistically relevant, and conservative results than the frequentist-NMA. Conclusion Some TH regrowth can be expected from most AGA treatments ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fmed.2022.998623 |
| DOI: | 10.3389/fmed.2022.998623/full |
| الاتاحة: | http://dx.doi.org/10.3389/fmed.2022.998623 https://www.frontiersin.org/articles/10.3389/fmed.2022.998623/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.79E541A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmed.2022.998623 |
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