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Flow chart of study.
| العنوان: | Flow chart of study. |
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| المؤلفون: | Yuxing Tai, Xiaoqian Yang, Xiaochao Gang, Zhengri Cong, Sixian Wang, Peizhe Li, Mingjun Liu |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, progressive condition defined, july december 2023, explore metabolite biomarkers, collect potential literature, insulin receptor sensitivity, diabetic obese patients, potential metabolic biomarkers, potential biomarkers, metabolic pathways, insulin production, |
| الوصف: | Background Type 2 diabetes mellitus (T2DM) is a chronic and progressive condition defined by hyperglycemia caused by abnormalities in insulin production, insulin receptor sensitivity, or both. Several studies have revealed that higher body mass index (BMI) is associated with increasing risk of developing diabetes. In this study, we perform a protocol for systematic review to explore metabolite biomarkers that could be used to identify T2DM in obese subjects. Methods The protocol of this review was registered in PROSPERO (CRD42023405518). Three databases, EMBASE, PubMed, and Web of Science were selected to collect potential literature from their inceptions to July December 2023. Data for collection will include title, authors, study subjects, publication date, sample size, detection and analytical platforms, participant characteristics, biological samples, confounding factors, methods of statistical analysis, the frequency and directions of changes in potential metabolic biomarkers, and major findings. Pathway analysis of differential metabolites will be performed with MetaboAnalyst 5.0 based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Human Metabolome Database. Results The results of this systematic review will be published in a peer-reviewed journal. Conclusion This systematic review will summarize the potential biomarkers and metabolic pathways to provide a new reference for the prevention and treatment of T2DM in obese subjects. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Flow_chart_of_study_/25014745 |
| DOI: | 10.1371/journal.pone.0296749.g001 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0296749.g001 https://figshare.com/articles/figure/Flow_chart_of_study_/25014745 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.79B617A9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0296749.g001 |
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