Academic Journal
Long‐term approach to patients with postsurgical seizures
| العنوان: | Long‐term approach to patients with postsurgical seizures |
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| المؤلفون: | Ryzí, Michal, Ošlejšková, Hana, Rektor, Ivan, Novák, Zdeněk, Hemza, Jan, Chrastina, Jan, Svoboda, Michal, Hermanová, Markéta, Brázdil, Milan |
| المساهمون: | Czech Ministry of Health, CEITEC- Central European Institute of Technology, European Regional Development Fund, Student project Specific Research |
| المصدر: | Epilepsia ; volume 57, issue 4, page 597-604 ; ISSN 0013-9580 1528-1167 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Objective The main purpose of the study was to analyze the long‐term outcomes and therapeutic approaches for patients with seizures within the first year after surgery. The secondary aim of the study was to evaluate the relationship between 1‐year outcome and long‐term outcome and choice of therapy. Methods Our study was a retrospective investigation of the long‐term outcomes of 95 patients (33.5% of all surgically treated patients) with seizure recurrence in the first year after surgery. The patients had follow‐up visits for >5 years. Results At the 5‐year follow‐up visit ( FU 5), 28 (29.5%) of the 95 patients were completely seizure‐free (International League Against Epilepsy ( ILAE ) class 1), 17 (17.9%) had auras only ( ILAE class 2), and 21 (22.1%) were unimproved ( ILAE classes 5 and 6). Statistically significant factors for these long‐term outcomes were the focus localization of the epilepsy, preoperative MRI findings, and postoperative follow‐up results in the first year. The patients with <3 seizure days in the first postoperative year ( ILAE 3) represented 53.6% of the seizure‐free patients at FU 5; the patients with auras in the first year constituted 64.7% of the patients with only auras at FU 5; and the patients unimproved in the first year represented 76.2% of the unimproved patients at FU 5. Significance Postoperative outcome depends to a certain extent on the outcome achieved in the first postoperative year. More than one third of the patients with postoperative seizures reached a long‐term seizure‐free outcome, and more than half of them did not experience disabling seizures in the last outcome year. The most therapeutic options were used in patients who were minimally influenced by the operation; the majority of patients with considerable improvement because of the operation do not use any other add‐on antiepileptic drugs or other kinds of therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/epi.13343 |
| الاتاحة: | http://dx.doi.org/10.1111/epi.13343 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fepi.13343 https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.13343 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.79B26934 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/epi.13343 |
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