Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R

التفاصيل البيبلوغرافية
العنوان:	Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R
المؤلفون:	Kojima, Toshiyuki, Tsuchiya, Kiichiro, Ikemizu, Shinji, Yoshikawa, Soichiro, Yamanishi, Yoshinori, Watanabe, Mamoru, Karasuyama, Hajime
المصدر:	Scientific Reports ; volume 6, issue 1 ; ISSN 2045-2322
بيانات النشر:	Springer Science and Business Media LLC
سنة النشر:	2016
الوصف:	CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known ligand of CD200R and broadly distributed in a variety of cell types. Here we identified novel CD200 homologues, designated iSEC1 and iSEC2, that are expressed exclusively by secretory cell lineages in the gastrointestinal epithelium while authentic CD200 is expressed by none of epithelial cells including secretory cells. Both iSEC1 and iSEC2 could bind to CD200R but not other members of the CD200R family. Notably, CD200R expression was confined to intraepithelial lymphocytes (IELs) among cells in the gastrointestinal epithelium. Binding of iSEC1 to CD200R on IELs resulted in the suppression of cytokine production and cytolytic activity by activated IELs. Thus, iSEC1 is a previously unappreciated CD200R ligand with restricted expression in gastrointestinal secretory cells and may negatively regulate mucosal immune responses.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1038/srep36457
الاتاحة:	http://dx.doi.org/10.1038/srep36457 https://www.nature.com/articles/srep36457.pdf https://www.nature.com/articles/srep36457
Rights:	https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0
رقم الانضمام:	edsbas.79AC4A4D
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1038/srep36457