Academic Journal
Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial
| العنوان: | Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial |
|---|---|
| المؤلفون: | Aghasadeghi, Mohammad Reza, Zaheri Birgani, Mohammad Ali, Jamalimoghadamsiyahkali, Saeedreza, Hosamirudsari, Hadiseh, Moradi, Ali, Jafari-Sabet, Majid, Sadigh, Nooshin, Rahimi, Pooneh, Tavakoli, Rezvan, Hamidi-Fard, Mojtaba, Bahramali, Golnaz, Parmoon, Zohal, Arjmand Hashjin, Sina, Mirzajani, Ghasem, Kouhkheil, Reza, Roshangaran, Somayeh, Khalaf, Samineh, Khademi Nadoushan, Mohammad, Gholamiyan Yousef Abad, Ghazaleh, Shahryarpour, Nima, Izadi, Mohammad, Zendedel, Abolfazl, Jahanfar, Shayesteh, Dadras, Omid, SeyedAlinaghi, SeyedAhmad, Hackett, Daniel |
| المصدر: | Frontiers in Immunology ; volume 15 ; ISSN 1664-3224 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2024 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Objective Spirulina ( arthrospira platensis ) is a cyanobacterium proven to have anti-inflammatory, antiviral, and antioxidant effects. However, the effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19 is currently unclear. This study aimed to evaluate the efficacy and safety of high-dose Spirulina platensis for SARS-CoV-2 infection. Study Design We conducted a randomized, controlled, open-label trial involving 189 patients with COVID-19 who were randomly assigned in a 1:1 ratio to an experimental group that received 15.2g of Spirulina supplement plus standard treatment (44 non-intensive care unit (non-ICU) and 47 ICU), or to a control group that received standard treatment alone (46 non-ICU and 52 ICU). The study was conducted over six days. Immune mediators were monitored on days 1, 3, 5, and 7. The primary outcome of this study was mortality or hospital discharge within seven days, while the overall discharge or mortality was considered the secondary outcome. Results Within seven days, there were no deaths in the Spirulina group, while 15 deaths (15.3%) occurred in the control group. Moreover, within seven days, there was a greater number of patients discharged in the Spirulina group (97.7%) in non-ICU compared to the control group (39.1%) (HR, 6.52; 95% CI, 3.50 to 12.17). Overall mortality was higher in the control group (8.7% non-ICU, 28.8% ICU) compared to the Spirulina group (non-ICU HR, 0.13; 95% CI, 0.02 to 0.97; ICU, HR, 0.16; 95% CI, 0.05 to 0.48). In non-ICU, patients who received Spirulina showed a significant reduction in the levels of IL-6, TNF-α, IL-10, and IP-10 as intervention time increased. Furthermore, in ICU, patients who received Spirulina showed a significant decrease in the levels of MIP-1α and IL-6. IFN-γ levels were significantly higher in the intervention group in both ICU and non-ICU subgroups as intervention time increased. No side effects related to Spirulina supplements were observed during the trial. Conclusion High-dose Spirulina supplements ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fimmu.2024.1332425 |
| DOI: | 10.3389/fimmu.2024.1332425/full |
| الاتاحة: | http://dx.doi.org/10.3389/fimmu.2024.1332425 https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332425/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.79965A69 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2024.1332425 |
|---|