Academic Journal
Mining the Prognostic Role of DNA Methylation Heterogeneity in Lung Adenocarcinoma
| العنوان: | Mining the Prognostic Role of DNA Methylation Heterogeneity in Lung Adenocarcinoma |
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| المؤلفون: | Hongying Liao, Xiaolong Luo, Yisheng Huang, Xingping Yang, Yuzhen Zheng, Xianyu Qin, Jian Tan, Piao Shen, Renjiang Tian, Weijie Cai, Xiaoshun Shi, Xiaofang Deng |
| المصدر: | Disease Markers, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Purpose. DNA methylation heterogeneity is a type of tumor heterogeneity in the tumor microenvironment, but studies on the identification of the molecular heterogeneity of the lung adenocarcinoma genome with respect to DNA methylation sites and their roles in lung cancer progression and prognosis are scarce. Methods. Prognosis-associated DNA methylation subtypes were filtered by the Cox proportional hazards model and then established by unsupervised cluster analysis. Association analysis of these subtypes with clinical features and functional analysis of annotated genes potentially affected by methylation sites were performed. The robustness of the model was further tested by a Bayesian network classifier. Results. Over 7 thousand methylation sites were associated with lung adenocarcinoma prognosis. We identified seven molecular methylation subtypes, including 630 methylation sites. The subtypes yielded the most stable results for differentiating methylation profiles, prognosis, and gene expression patterns. The annotated genes potentially affected by these methylation sites are enriched in biological processes such as morphogenesis and cell adhesion, but their individual impact on the tumor microenvironment and prognosis is multifaceted. Discussion. We revealed that DNA methylation heterogeneity could be clustered and associated with the clinical features and prognosis of lung adenocarcinoma, which could lead to the development of a novel molecular tool for clinical evaluation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1875-8630 |
| Relation: | http://dx.doi.org/10.1155/2022/9389372; https://doaj.org/toc/1875-8630; https://doaj.org/article/f1ca791ff7b5408d91dad00c2bec5630 |
| DOI: | 10.1155/2022/9389372 |
| الاتاحة: | https://doi.org/10.1155/2022/9389372 https://doaj.org/article/f1ca791ff7b5408d91dad00c2bec5630 |
| رقم الانضمام: | edsbas.798ECC7B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18758630 |
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| DOI: | 10.1155/2022/9389372 |