Academic Journal
Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
| العنوان: | Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease |
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| المؤلفون: | van den Berge, M., Hop, W.C.J., van der Molen, T., van Noord, J.A., Creemers, J.P.H.M., Schreurs, A.J.M., Wouters, E.F.M., Postma, D.S., the COSMIC (COPD and Seretide: a Multi-Center Intervention and Characterization), study group |
| المصدر: | van den Berge , M , Hop , W C J , van der Molen , T , van Noord , J A , Creemers , J P H M , Schreurs , A J M , Wouters , E F M , Postma , D S & the COSMIC (COPD and Seretide: a Multi-Center Intervention and Characterization) , S G 2012 , ' Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease ' , Respiratory Research , vol. 13 , 44 . https://doi.org/10.1186/1465-9921-13-44 |
| سنة النشر: | 2012 |
| المجموعة: | Maastricht University Research Publications |
| الوصف: | BACKGROUND: Frequent exacerbations induce a high burden to Chronic Obstructive Pulmonary Disease (COPD). We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticasone after a 3-month run-in treatment period with salmeterol/fluticasone in patients with COPD. METHODS: In 373 patients, we evaluated diary cards for symptoms, Peak Expiratory Flow (PEF), and salbutamol use and assessed their course during exacerbations. RESULTS: There were 492 exacerbations in 224 patients. The level of symptoms of cough, sputum, dyspnea and nocturnal awakening steadily increased from 2 weeks prior to exacerbation, with a sharp rise during the last week. Symptoms of cough, sputum, and dyspnea reverted to baseline values at different rates (after 4, 4, and 7 weeks respectively), whereas symptoms of nocturnal awakening were still increased after eight weeks. The course of symptoms was similar around a first and second exacerbation. Increases in symptoms and salbutamol use and decreases in PEF were associated with a higher risk to develop an exacerbation, but with moderate predictive values, the areas under the receiver operating curves ranging from 0.63 to 0.70. CONCLUSIONS: Exacerbations of COPD are associated with increased symptoms that persist for weeks and the course is very similar between a first and second exacerbation. COPD exacerbations are preceded by increased symptoms and salbutamol use and lower PEF, yet predictive values are too low to warrant daily use in clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/1465-9921-13-44 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/fcffa888-63b5-4c6e-8902-5f6d8eeb3fd8 https://doi.org/10.1186/1465-9921-13-44 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7980CB66 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1465-9921-13-44 |
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