Academic Journal
Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma
| العنوان: | Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma |
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| المؤلفون: | Vercellino, Laetitia, de Jong, Dorine, Dercle, Laurent, Hosten, Benoit, Braumuller, Brian, Das, Jeeban, Paul, Deng, Aileen, Moya-Plana, Antoine, A’keen, Camry, Yeh, Randy, Merlet, Pascal, Baroudjian, Barouyr, Salvatore, Mary, M, Capaccione, Kathleen, M |
| المساهمون: | Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Université Paris Cité (UPCité), Memorial Sloan Kettering Cancer Center (MSKCC), Columbia University Medical Center (CUMC), Columbia University New York, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S 1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Novant Health Cancer Institute - Elizabeth Charlotte, NC, USA (NHCIE), Département de cancérologie cervico-faciale Gustave Roussy (CCF), Institut Gustave Roussy (IGR), Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Memorial Sloane Kettering Cancer Center New York |
| المصدر: | ISSN: 2075-4418 ; Diagnostics ; https://inserm.hal.science/inserm-03924844 ; Diagnostics, 2022, 12 (5), pp.1116. ⟨10.3390/diagnostics12051116⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | PET imaging, melanoma, molecular targeting, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Melanoma is a deadly disease that often exhibits relentless progression and can have both early and late metastases. Recent advances in immunotherapy and targeted therapy have dramatically increased patient survival for patients with melanoma. Similar advances in molecular targeted PET imaging can identify molecular pathways that promote disease progression and therefore offer physiological information. Thus, they can be used to assess prognosis, tumor heterogeneity, and identify instances of treatment failure. Numerous agents tested preclinically and clinically demonstrate promising results with high tumor-to-background ratios in both primary and metastatic melanoma tumors. Here, we detail the development and testing of multiple molecular targeted PET-imaging agents, including agents for general oncological imaging and those specifically for PET imaging of melanoma. Of the numerous radiopharmaceuticals evaluated for this purpose, several have made it to clinical trials and showed promising results. Ultimately, these agents may become the standard of care for melanoma imaging if they are able to demonstrate micrometastatic disease and thus provide more accurate information for staging. Furthermore, these agents provide a more accurate way to monitor response to therapy. Patients will be able to receive treatment based on tumor uptake characteristics and may be able to be treated earlier for lesions that with traditional imaging would be subclinical, overall leading to improved outcomes for patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35626272; inserm-03924844; https://inserm.hal.science/inserm-03924844; https://inserm.hal.science/inserm-03924844/document; https://inserm.hal.science/inserm-03924844/file/diagnostics-12-01116.pdf; PUBMED: 35626272; PUBMEDCENTRAL: PMC9139963 |
| DOI: | 10.3390/diagnostics12051116 |
| الاتاحة: | https://inserm.hal.science/inserm-03924844 https://inserm.hal.science/inserm-03924844/document https://inserm.hal.science/inserm-03924844/file/diagnostics-12-01116.pdf https://doi.org/10.3390/diagnostics12051116 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7954F14D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/diagnostics12051116 |
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