Academic Journal
Vδ2 T cells are associated with favorable clinical outcomes in patients with bladder cancer and their tumor reactivity can be boosted by BCG and zoledronate treatments.
| العنوان: | Vδ2 T cells are associated with favorable clinical outcomes in patients with bladder cancer and their tumor reactivity can be boosted by BCG and zoledronate treatments. |
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| المؤلفون: | Nguyen, S., Chevalier, M.F., Benmerzoug, S., Cesson, V., Schneider, A.K., Rodrigues-Dias, S.C., Dartiguenave, F., Lucca, I., Jichlinski, P., Roth, B., Nardelli-Haefliger, D., Derré, L. |
| المصدر: | Journal for immunotherapy of cancer, vol. 10, no. 8, pp. e004880 |
| سنة النشر: | 2022 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, BCG Vaccine/therapeutic use, Humans, Mice, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocyte Subsets, Tumor Microenvironment, Urinary Bladder Neoplasms/drug therapy, Zoledronic Acid/pharmacology, Zoledronic Acid/therapeutic use, Immunity, Immunotherapy, Urinary Bladder Neoplasms |
| الوصف: | Background Bladder cancer is an important public health concern due to its prevalence, high risk of recurrence and associated cost of management. Although BCG instillation for urothelial cancer treatment is the gold-standard treatment for this indication, repeated BCG treatments are associated with significant toxicity and failure, underlining the necessity for alternative or complementary immunotherapy and overall for better understanding of T-cell responses generated within bladder mucosa. Tumor-infiltrating lymphocytes (TIL) have long been recognized as a crucial component of the tumor microenvironment for the control of tumor. Among TIL, unconventional γδ T cells sparked interest due to their potent antitumor functions. Although preclinical mouse xenograft models demonstrated the relevance of using γδ T cells as a novel therapy for bladder cancer (BCa), the contribution of γδ T cells in BCa patients' pathology remains unaddressed.Methods Therefore, we first determined the proportion of intratumor γδ T cells in muscle-invasive patients with BCa by deconvoluting data from The Cancer Genome Atlas (TCGA) and the frequency of blood Vδ1, Vδ2, and total γδ T cells, by flow cytometry, from 80 patients with BCa (40 non-muscle and 40 muscle-invasive patients with BCa), as well as from 20 age-matched non-tumor patients. Then we investigated in vitro which treatment may promote BCa tumor cell recognition by γδ T cells.Results We observed a decrease of γδ T-cell abundance in the tumor compared with corresponding normal adjacent tissue, suggesting that the tumor microenvironment may alter γδ T cells. Yet, high intratumor γδ T-cell proportions were significantly associated with better patient survival outcomes, potentially due to Vδ2 T cells. In the blood of patients with BCa, we observed a lower frequency of total γδ, Vδ1, and Vδ2 T cells compared with non-tumor patients, similarly to the TCGA analysis. In addition, a favorable clinical outcome is associated with a high frequency of circulating γδ T cells, which might be ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36002184; info:eu-repo/semantics/altIdentifier/eissn/2051-1426; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_430EBCEC57573; https://serval.unil.ch/notice/serval:BIB_430EBCEC5757; https://serval.unil.ch/resource/serval:BIB_430EBCEC5757.P001/REF.pdf |
| DOI: | 10.1136/jitc-2022-004880 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_430EBCEC5757 https://doi.org/10.1136/jitc-2022-004880 https://serval.unil.ch/resource/serval:BIB_430EBCEC5757.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_430EBCEC57573 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.7910BB29 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/jitc-2022-004880 |
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