Report
Transmission of Cervid prions to Humanized Mice Demonstrates the Zoonotic Potential of CWD
| العنوان: | Transmission of Cervid prions to Humanized Mice Demonstrates the Zoonotic Potential of CWD |
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| المؤلفون: | Hannaoui, Samia, Zemlyankina, Irina, Chang, Sheng Chun, Arifin, Maria Immaculata, Béringue, Vincent, Mckenzie, Debbie, Schatzl, Hermann, Gilch, Sabine |
| المساهمون: | University of Calgary, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | https://hal.science/hal-04524648 ; 2024. |
| بيانات النشر: | CCSD |
| سنة النشر: | 2024 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | Prions cause infectious and fatal neurodegenerative diseases in mammals. Chronic wasting disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed animals. Potential transmission to humans of CWD is a growing concern due to its increasing prevalence. Here, we provide the strongest evidence to date supporting the zoonotic potential of CWD prions, and their probable materialization in humans using mice expressing human prion protein (PrP) as an infection model. Inoculation of these mice with deer CWD isolates resulted in atypical clinical manifestations, with prion seeding activity and efficient transmissible infectivity in the brain and, remarkably, in feces. Intriguingly, the protease-resistant PrP in the brain resembled that found in a familial human prion disease and was transmissible upon second passage. Our results are the first evidence that CWD can infect humans with a distinctive clinical presentation, signature, and tropism, and might be transmissible between humans while current diagnostic assays might fail to detect it. These findings have major implications for public health and CWD management. |
| نوع الوثيقة: | report |
| اللغة: | English |
| Relation: | BIORXIV: 2022.04.19.488833 |
| DOI: | 10.1101/2022.04.19.488833 |
| الاتاحة: | https://hal.science/hal-04524648 https://doi.org/10.1101/2022.04.19.488833 |
| Rights: | http://creativecommons.org/licenses/by/ |
| رقم الانضمام: | edsbas.79070EBC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1101/2022.04.19.488833 |
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