Academic Journal
Acute exercise does not modify brain activity and memory performance in APP/PS1 mice
| العنوان: | Acute exercise does not modify brain activity and memory performance in APP/PS1 mice |
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| المؤلفون: | Stein, Angelica Miki, Munive, Victor, Fernandez, Ana M., Núñez, Ángel, Aleman, Ignacio Torres |
| المساهمون: | UAM. Departamento de Anatomía, Histología y Neurociencia |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2017 |
| المجموعة: | Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| مصطلحات موضوعية: | Alzheimer's disease, Age risk factor, Electrocorticogram (ECG) recordings, Electroencephalography, Medicina |
| الوصف: | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Age is the main risk factor for AlzheimerÂs disease (AD). With an increasingly aging population, development of affordable screening techniques to determine cognitive status will help identify population-At-risk for further follow-up. Because physical exercise is known to modulate cognitive performance, we used it as a functional test of cognitive health. Mice were submitted to treadmill running at moderate speed for 30 min, and their brain activity was monitored before and after exercise using electrocorticogram (ECG) recordings. After exercise, normal, but not APP/PS1 mice, a well established AD model, showed significantly increased ECG theta rhythm. At the same time normal, but not AD mice, showed significantly enhanced performance in a spatial memory test after exercise. Therefore, we postulate that a running bout coupled to pre-And post-exercise brain activity recordings will help identify individuals with cognitive alterations, by determining the presence or absence of exercise-specific changes in brain activity. Work in humans using a bout of moderate exercise plus electroencephalography, a clinically affordable procedure, is warranted. ; This work was funded by grants SAF2013-40710-R, SAF2016-76462 AEI/FEDER, and by Ciberned. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | PLos One; https://doi.org/10.1371/journal.pone.0178247; Gobierno de España. SAF2013-40710-R; Gobierno de España. SAF2016-76462 AEI/FEDER; PLos One 12.5 (2017): e0178247; http://hdl.handle.net/10486/680107; e0178247-1; e0178247-11; 12 |
| DOI: | 10.1371/journal.pone.0178247 |
| الاتاحة: | http://hdl.handle.net/10486/680107 https://doi.org/10.1371/journal.pone.0178247 |
| Rights: | © 2017 Miki Stein et al. ; Reconocimiento ; openAccess |
| رقم الانضمام: | edsbas.78F688B9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0178247 |