التفاصيل البيبلوغرافية
| العنوان: |
List of peptide sequences. |
| المؤلفون: |
Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Neuroscience, Ecology, Immunology, Cancer, Infectious Diseases, Virology, neurons producing orexin, narcolepsy type 1, mediated immunity rather, differential binding capacity, also named hypocretin, serum immunoglobin g, nt1 patient cohort, unbiased random peptide, specific antigens targeted, ohc control group, mer peptides derived, nt1 serum igg, targeted methodologies, specific autoantibodies, various peptides, statistically significant, selective loss, selected using, rtn4 proteins, previous studies, orexinergic neuron, ohcs ), lateral hypothalamus, hypersomnolence complaints |
| الوصف: |
Narcolepsy type 1 (NT1) is an enigmatic sleep disorder characterized by the selective loss of neurons producing orexin (also named hypocretin) in the lateral hypothalamus. Although NT1 is believed to be an autoimmune disease, the orexinergic neuron-specific antigens targeted by the pathogenic immune response remain elusive. In this study, we evaluated the differential binding capacity of various peptides to serum immunoglobin G from patients with NT1 and other hypersomnolence complaints (OHCs). These peptides were selected using an unbiased phage display technology or based on their significant presence in the serum of NT1 patients as identified from previous studies. Although the subtractive biopanning strategy successfully enriched phage clones with high reactivity against NT1 serum IgG, the 101 randomly selected individual phage clones could not differentiate the sera from NT1 and OHC. Compared to the OHC control group, serum from several NT1 patients exhibited increased reactivity to the 12-mer peptides derived from TRBV7, BCL-6, NRXN1, RXRG, HCRT, and RTN4 proteins, although not statistically significant. Collectively, employing both unbiased and targeted methodologies, we were unable to detect the presence of specific autoantibodies in our NT1 patient cohort. This further supports the hypothesis that the autoimmune response in NT1 patients likely stems primarily from T cell-mediated immunity rather than humoral immunity. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/List_of_peptide_sequences_/25344331 |
| DOI: |
10.1371/journal.pone.0297625.t002 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0297625.t002
https://figshare.com/articles/dataset/List_of_peptide_sequences_/25344331 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.78E71075 |
| قاعدة البيانات: |
BASE |