التفاصيل البيبلوغرافية
| العنوان: |
Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity-APREVIEWrandomized clinical trial |
| المؤلفون: |
Dorenbos, Elke, Drummen, Mathijs, Adam, Tanja, Rijks, Jesse, Winkens, Bjorn, Alfredo Martinez, J., Navas-Carretero, Santiago, Stratton, Gareth, Swindell, Nils, Stouthart, Pauline, Mackintosh, Kelly, Mcnarry, Melitta, Tremblay, Angelo, Fogelholm, Mikael, Raben, Anne, Westerterp-Plantenga, Margriet, Vreugdenhil, Anita |
| المساهمون: |
Department of Food and Nutrition, Nutrition Science |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
dietary protein, glycaemic index, glycaemic load, physical activity, pubertal insulin resistance, BODY-COMPOSITION, PHYSICAL-ACTIVITY, OBESE CHILDREN, WEIGHT-LOSS, PUBERTAL CHANGES, SENSITIVITY, INTERVENTION, GLUCOSE, YOUTH, QUESTIONNAIRE, 3143 Nutrition, General medicine, internal medicine and other clinical medicine |
| الوصف: |
Background Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA-IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity. Methods Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI >= 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. Anthropometric and cardiometabolic parameters, puberty, dietary intake and physical activity (PA) were measured and effects on HOMA-IR were analyzed. Results 126 adolescents were included in this study (13.6 +/- 2.2 years, BMI z-score 3.04 +/- 0.66, HOMA-IR 3.48 +/- 2.28, HP n = 68, MP n = 58). At 2 years, changes in protein intake were not significantly different between timepoints or intervention groups and no effects of the intervention on IR were observed. The retention rate was 39%, while no compliance to the diets was observed. Conclusions The PREVIEW study observed no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR because of lack of feasibility, due to insufficient retention and dietary compliance after 2 years. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
FP7 Food, Agriculture and Fisheries, Biotechnology, Grant/Award Number: 312057; Dorenbos , E , Drummen , M , Adam , T , Rijks , J , Winkens , B , Alfredo Martinez , J , Navas-Carretero , S , Stratton , G , Swindell , N , Stouthart , P , Mackintosh , K , Mcnarry , M , Tremblay , A , Fogelholm , M , Raben , A , Westerterp-Plantenga , M & Vreugdenhil , A 2021 , ' Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity-APREVIEWrandomized clinical trial ' , Pediatric obesity , vol. 16 , no. 1 , 12702 . https://doi.org/10.1111/ijpo.12702; http://hdl.handle.net/10138/339327; cd07e1df-babd-4a2e-83fe-05348662df3e; 000549098200001 |
| الاتاحة: |
http://hdl.handle.net/10138/339327 |
| Rights: |
cc_by_nc ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.78C0A321 |
| قاعدة البيانات: |
BASE |