Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents
| العنوان: | Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents |
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| المؤلفون: | Shih, Tzenge-lien |
| سنة النشر: | 2023 |
| المجموعة: | Tamkang University Institutional Repository (TKUIR) / 淡江大學機構典藏 |
| مصطلحات موضوعية: | 1,2,3-triazole, benzenesulfonamide, click chemistry, flavonol, human non-small-cell lung cancer cells, hybrid molecules |
| الوصف: | Background The design and synthesis of hybrid molecules will explore finding new drugs. Objectives The synthesized hybrid molecules to evaluate their biological properties. Methods Apply click chemistry to tether flavonols and benzenesulfonamide. Results Two drug candidates show potential against lung cancer. Conclusions Two drug candidates did not affect the normal cells and provided a new drug design route. ; 補正完畢 ; TWN |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | 104 bytes; text/html |
| اللغة: | English |
| Relation: | Journal of the Chinese Chemical Society 70(10), p.1924-1936; https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/124672; https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/124672/1/index.html |
| DOI: | 10.1002/jccs.202300279 |
| الاتاحة: | https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/124672 https://doi.org/10.1002/jccs.202300279 https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/124672/1/index.html |
| رقم الانضمام: | edsbas.78AF970F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jccs.202300279 |
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