Academic Journal
Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging
| العنوان: | Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging |
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| المؤلفون: | Lauwerends, Lorraine J., Zweedijk, Bo E., Galema, Hidde A., Neijenhuis, Lisanne K.A., Dekker-Ensink, Neeltje G., Baatenburg de Jong, Robert J., Verhoef, Cornelis, Bhairosingh, Shadhvi S., Kuppen, Peter J.K., Vahrmeijer, Alexander L., van Ginhoven, Tessa M., Koljenović, Senada, Koppes, Sjors A., Hilling, Denise E., Keereweer, Stijn |
| المصدر: | Lauwerends , L J , Zweedijk , B E , Galema , H A , Neijenhuis , L K A , Dekker-Ensink , N G , Baatenburg de Jong , R J , Verhoef , C , Bhairosingh , S S , Kuppen , P J K , Vahrmeijer , A L , van Ginhoven , T M , Koljenović , S , Koppes , S A , Hilling , D E & Keereweer , S 2024 , ' Tumour Marker Expression in Head and Neck Malignancies to Identify Potential Targets for Intraoperative Molecular Near-Infrared Imaging ' , Molecular .... |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Background: Oral and laryngeal squamous cell carcinoma (OSCC and LSCC) and papillary thyroid carcinoma (PTC) are common head and neck cancers (HNCs) typically treated surgically. Challenges in tumour delineation often lead to inadequate resection margins in OSCC and LSCC, and missed multifocality in PTC. Fluorescence imaging (FLI) using near-infrared tumour-targeting tracers may improve intraoperative identification of malignancy, facilitating precise excision. This study evaluates six potential FLI targets in OSCC, LSCC and PTC. Materials and methods: Immunohistochemical staining was performed on OSCC (n = 20), LSCC (n = 10) and PTC (n = 10), assessing CEA, c-Met, EpCAM, EGFR, integrin αvβ6 and VEGF-α. Expression was scored (0–12) using the total immunostaining score (TIS) system, and categorized into absent (TIS 0), low (TIS 1–5), moderate (TIS 6–8) or high (TIS 9–12). Results: Integrin αvβ6 showed significant overexpression in OSCC (TIS: 12; p < 0.001) and LSCC (TIS: 8; p = 0.002), with 80% of OSCC and 90% of LSCC exhibiting moderate-high expression. Similarly, EGFR expression was moderate-high in most OSCC (87.5%; TIS: 8) and universally high in LSCC (100%; TIS: 12). In PTC, EGFR and VEGF-α expressions were low-moderate, but significantly higher than in healthy tissue (TIS: 6; p < 0.006). Conclusion: This study highlights integrin αvβ6 and EGFR as viable FLI targets in OSCC and LSCC, especially integrin αvβ6 for tumour margin delineation. In PTC, despite lower expressions, the significant overexpression of VEGF-α, c-MET, and EGFR suggests their potential as FLI targets. Our findings support the development of tumour-targeted FLI tracers to improve surgical precision in HNC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1007/s40291-024-00742-w |
| الاتاحة: | https://pure.eur.nl/en/publications/623ed705-90e2-4f52-9bb9-44cc1e2f3b44 https://doi.org/10.1007/s40291-024-00742-w https://pure.eur.nl/ws/files/172865569/s40291-024-00742-w.pdf http://www.scopus.com/inward/record.url?scp=85203312310&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.788DCB41 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s40291-024-00742-w |
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