Academic Journal
Neonatal Early Onset Sepsis (EOS) Calculator plus Universal Serial Physical Examination (SPE): A Prospective Two-Step Implementation of a Neonatal EOS Prevention Protocol for Reduction of Sepsis Workup and Antibiotic Treatment
| العنوان: | Neonatal Early Onset Sepsis (EOS) Calculator plus Universal Serial Physical Examination (SPE): A Prospective Two-Step Implementation of a Neonatal EOS Prevention Protocol for Reduction of Sepsis Workup and Antibiotic Treatment |
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| المؤلفون: | Cavigioli, Francesco, Viaroli, Francesca, Daniele, Irene, Paroli, Michela, Guglielmetti, Luigi, Esposito, Elena, Cerritelli, Francesco, Zuccotti, Gianvincenzo, Lista, Gianluca |
| المساهمون: | F. Cavigioli, F. Viaroli, I. Daniele, M. Paroli, L. Guglielmetti, E. Esposito, F. Cerritelli, G. Zuccotti, G. Lista |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | antibiotic, early onset sepsi, infection, mortality, newborn, serial clinical examination, Settore MED/38 - Pediatria Generale e Specialistica |
| الوصف: | Current neonatal early-onset sepsis (EOS) guidelines lack consensus. Recent studies suggest three different options for EOS risk assessment among infants born >= 35 wks gestational age (GA), leading to different behaviors in the sepsis workup and antibiotic administration. A broad disparity in clinical practice is found in Neonatal Units, with a large number of non-infected newborns evaluated and treated for EOS. Broad spectrum antibiotics in early life may induce different short- and long-term adverse effects, longer hospitalization, and early mother-child separation. In this single-center prospective study, a total of 3002 neonates born in three periods between 2016 and 2020 were studied, and three different workup algorithms were compared: the first one was based on the categorical risk assessment; the second one was based on a Serial Physical Examination (SPE) strategy for infants with EOS risk factors; the third one associated an informatic tool (Neonatal EOS calculator) with a universal extension of the SPE strategy. The main objective of this study was to reduce the number of neonatal sepsis workups and the rate of antibiotic administration and favor rooming-in and mother-infant bonding without increasing the risk of sepsis and mortality. The combined strategy of universal SPE with the EOS Calculator showed a significant reduction of laboratory tests (from 33% to 6.6%; p < 0.01) and antibiotic treatments (from 8.5% to 1.4%; p < 0.01) in term and near-term newborns. EOS and mortality did not change significantly during the study period. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36009958; info:eu-repo/semantics/altIdentifier/wos/WOS:000846338600001; volume:11; issue:8; firstpage:1; lastpage:10; numberofpages:10; journal:ANTIBIOTICS; https://hdl.handle.net/2434/951775; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137361123 |
| DOI: | 10.3390/antibiotics11081089 |
| الاتاحة: | https://hdl.handle.net/2434/951775 https://doi.org/10.3390/antibiotics11081089 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7885686C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/antibiotics11081089 |
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