Academic Journal
Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts
| العنوان: | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
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| المؤلفون: | Khalifah, Bashayer A., Alghamdi, Shareefa A., Alhasan, Ali H. |
| المصدر: | Frontiers in Bioengineering and Biotechnology ; volume 11 ; ISSN 2296-4185 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS). Intron retention (IR) is a major inducer of spliceopathies where two or more introns remain in the final mature mRNA and account for many intronic expansion diseases. Potential removal of such introns for therapeutic purposes can be feasible when utilizing bioinformatics, catalytic RNAs, and nano-drug delivery systems. Overcoming delivery challenges of catalytic RNAs was discussed in this review as a future perspective highlighting the significance of utilizing synthetic biology in addition to high throughput deep sequencing and computational approaches for the treatment of mis-spliced transcripts. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fbioe.2023.1244377 |
| DOI: | 10.3389/fbioe.2023.1244377/full |
| الاتاحة: | http://dx.doi.org/10.3389/fbioe.2023.1244377 https://www.frontiersin.org/articles/10.3389/fbioe.2023.1244377/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.78593145 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fbioe.2023.1244377 |
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