Academic Journal
Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI
| العنوان: | Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI |
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| المؤلفون: | Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian J, Gröber, Marie-Therese, Mair, Johannes, Kirchmair, Rudolf, Henninger, Benjamin, Franz, Wolfgang-Michael, Metzler, Bernhard |
| المصدر: | Open Heart ; volume 2, issue 1, page e000244 ; ISSN 2053-3624 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2015 |
| الوصف: | Objective To investigate the relationship between plasma fetuin-A, an anti-inflammatory glycoprotein which might be involved in myocardial healing after acute infarction, and infarct size, left ventricular (LV) function and dimensions as well as the occurrence of adverse remodelling at 4 months after acute ST segment elevation myocardial infarction (STEMI). Methods In this single-centre prospective, observational study, 89 patients underwent cardiac MR within the first week and 4 months after mechanical reperfusion for first STEMI. Infarct size, LV function and dimensions were assessed at both time points. Fetuin-A levels were determined from blood samples drawn at a median of 49 h (IQR 30–59 h) after STEMI by an immunofluorescent assay. Results Fetuin-A levels (median 568 µg/mL, IQR 478–763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05). Moreover, fetuin-A was related to the increase in the end-diastolic volume index (r=−0.383, p<0.001). According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months. Conclusions Circulating fetuin-A at day 2 after STEMI is related to acute and chronic infarct size, LV function and dimensions. In addition, it might be useful to identify patients at increased risk for adverse LV remodelling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/openhrt-2015-000244 |
| الاتاحة: | http://dx.doi.org/10.1136/openhrt-2015-000244 https://syndication.highwire.org/content/doi/10.1136/openhrt-2015-000244 |
| رقم الانضمام: | edsbas.7857690C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/openhrt-2015-000244 |
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