Academic Journal
Left atrial function, a new predictor of response to cardiac resynchronization therapy? ; Left atrial function, a new predictor of response to cardiac resynchronization therapy?: Left atrium and resynchronization
| العنوان: | Left atrial function, a new predictor of response to cardiac resynchronization therapy? ; Left atrial function, a new predictor of response to cardiac resynchronization therapy?: Left atrium and resynchronization |
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| المؤلفون: | Feneon, Damien, Behaghel, Albin, Bernard, Anne, Fournet, Maxime, Mabo, Philippe, Daubert, J-Claude, Leclercq, Christophe, Donal, Erwan |
| المساهمون: | Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie |
| المصدر: | ISSN: 1556-3871. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2015 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | echocardiography, left atrial function, cardiac resynchronization therapy, strain imaging, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Background - Cardiac resynchronization therapy (CRT) improves left ventricular (LV) function and induces LV remodeling, and it is an established therapy for advanced heart failure with prolonged QRS duration. One third of patients will not benefit from this invasive therapy. Objective - The purpose of this study was to evaluate whether left atrial (LA) strain imaging (ε) parameters could help in predicting the response in terms of LV reverse remodeling after CRT. Methods - A total of 79 patients who underwent CRT were evaluated with echography before implantation. LA function and LV function were assessed with M-mode, 2-dimensional echocardiography, Doppler, tissue Doppler velocity, and ε. LV reverse remodeling was defined as a >15% reduction in LV end-systolic volume. Results - At 6 months, 54 patients (68%) were responders to CRT. In multivariable logistic regression, LA systolic peak of strain rate (SRA) (odds ratio [OR} 10.5, 95% confidence interval [CI] 1.76-62.1, P = .01), left bundle branch block (OR 6.8, 95% CI 1.06-43.9, P = .04), ischemic cardiomyopathy (OR 3.93, 95% CI 1.07-14.4, P = .04), and LV preejection index (OR 1.03, 95% CI 1.01-1.05, P = .01) were associated with CRT response. With an SRA cutoff of -0.75%, the negative predictive value for predicting CRT response was 0.62. Conclusion - This study demonstrated the possible relevance of assessing LA function before CRT. SRA appeared to be a good predictor of CRT response. Integrating this LA function analysis into the multivariable assessment of patient candidates for CRT should be considered. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25896013; inserm-01172667; https://inserm.hal.science/inserm-01172667; https://inserm.hal.science/inserm-01172667/document; https://inserm.hal.science/inserm-01172667/file/Left%20atrium%20function.pdf; PUBMED: 25896013 |
| DOI: | 10.1016/j.hrthm.2015.04.021 |
| الاتاحة: | https://inserm.hal.science/inserm-01172667 https://inserm.hal.science/inserm-01172667/document https://inserm.hal.science/inserm-01172667/file/Left%20atrium%20function.pdf https://doi.org/10.1016/j.hrthm.2015.04.021 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.783BFE09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.hrthm.2015.04.021 |
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