التفاصيل البيبلوغرافية
| العنوان: |
Cross‐talk between α 1D ‐adrenoceptors and angiotensin II metabolites in vascular smooth muscle is involved in hypertension |
| المؤلفون: |
Gallardo-Ortiz, Itzell Alejandrina, López-Guerrero, Juan Javier, Del Valle-Mondragón, Leonardo, Ibarra, Maximiliano, López-Sánchez, Pedro, Villalobos-Molina, Rafael |
| المساهمون: |
Consejo Nacional de Ciencia y Tecnología, Universidad Nacional Autónoma de México |
| المصدر: |
The FASEB Journal ; volume 26, issue S1 ; ISSN 0892-6638 1530-6860 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2012 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Angiotensin II (Ang II) regulates arterial pressure via RAS, which might contribute to pathogenesis of genetic hypertension. However, local tissue RAS occur in most organs, and other Angs have biological actions: Ang III mimics Ang II; Ang IV acts via AT 4 R; Ang 1–7 acts via masR. In cardiovascular system α 1 ‐ARs regulate muscle contraction, they are implicated in cardiac malfunction. We explored the in vivo Ang II effect on α 1D ‐AR function in aorta and tail arteries of Wistar rats. Alzet pumps filled with Ang II (200 ng/kg/min/14 days) were implanted in male Wistar rats; simultaneously, rats were treated with BMY 7378 (10 mg/kg/day/14days) or losartan (1 mg/kg/day/14days). Blood pressure (BP) was measured, and arteries were used for contraction. Ang II increased BP (136 vs 104 mmHg). Losartan prevented hypertension, but BMY 7378 did not. Phenylephrine‐contracted aorta ~40% more in Ang II‐treated rats but not in tail artery. Antagonists blocked Ang II‐produced hypersensitivity in aorta. Plasma Ang III/IV increased ~4.6 fold; Ang 1–7 decreased 33%. Antagonists partially prevented the increase in Ang III/IV, but not in Ang 1–7 which increased. Data support crosstalk between Ang II and α 1D ‐AR in the vasculature, effect related to Ang II‐induced hypertension and hypersensitivity. Supported by CONACyT 167948 and PAPIIT IN214812 , UNAM ). |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1096/fasebj.26.1_supplement.1115.10 |
| الاتاحة: |
http://dx.doi.org/10.1096/fasebj.26.1_supplement.1115.10 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: |
edsbas.783764BE |
| قاعدة البيانات: |
BASE |