Academic Journal
Therapeutic Monitoring of Flutamide Using Aggregated Surface Enhanced Raman Spectroscopy (SERS) Substrates
| العنوان: | Therapeutic Monitoring of Flutamide Using Aggregated Surface Enhanced Raman Spectroscopy (SERS) Substrates |
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| المؤلفون: | Esther Jebakumari K. A., Murugasenapathi N. K., Udit Millenn R., Maged El-Kemary, Tamilarasan Palanisamy |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Biotechnology, Cancer, Space Science, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Aggregated silver nanoparticles, flutamide, Hofmeister effect, surface enhanced Raman spectroscopy (SERS), therapeutic monitoring |
| الوصف: | It is essential to monitor the blood level of flutamide (FLT) during prostate cancer treatment since the abnormal renal elimination due to pathophysiological factors hinders attaining steady-state drug concentration. This study reports a systematic investigation of aggregation of silver nanoparticles (AgNPs) based on Hofmeister effect and eventual change in surface-enhanced Raman spectroscopy (SERS) enhancement for the determination of FLT. Among the aggregants, MgSO 4 showed the maximum enhancement. The concentration of MgSO 4 , pH, and duration of aggregation were optimized for FLT detection. The aggregated AgNPs (a-AgNPs) SERS substrate enhanced the Raman signal of FLT by up to five-orders of magnitude under optimized conditions. The developed technique was able to determine FLT from 0.25 × 10 −3 μM to 250 μM with a limit of detection (LoD) of 1 pM. The application of the SERS substrate in practical analysis has been demonstrated using FLT-spiked human serum from 0 nM to 1000 nM with a detection limit of 0.3 nM. The reported Hofmeister series of AgNPs aggregation will assist in the development of SERS substrates for other analytes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Therapeutic_Monitoring_of_Flutamide_Using_Aggregated_Surface_Enhanced_Raman_Spectroscopy_SERS_Substrates/25324090 |
| DOI: | 10.6084/m9.figshare.25324090.v1 |
| الاتاحة: | https://doi.org/10.6084/m9.figshare.25324090.v1 https://figshare.com/articles/journal_contribution/Therapeutic_Monitoring_of_Flutamide_Using_Aggregated_Surface_Enhanced_Raman_Spectroscopy_SERS_Substrates/25324090 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.78098390 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.25324090.v1 |
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