Academic Journal
Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson's disease
| العنوان: | Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson's disease |
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| المؤلفون: | Zenuni, H, Bovenzi, R, Bissacco, J, Grillo, P, Simonetta, C, Mascioli, D, Pieri, M, Bernardini, S, Sancesario, GM, Stefani, A, Mercuri, NB, Schirinzi, T |
| المساهمون: | Zenuni, H, Bovenzi, R, Bissacco, J, Grillo, P, Simonetta, C, Mascioli, D, Pieri, M, Bernardini, S, Sancesario, G, Stefani, A, Mercuri, N, Schirinzi, T |
| بيانات النشر: | ELSEVIER SCIENCE INC |
| سنة النشر: | 2023 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Parkinson's disease, Biomarker, Cerebrospinal fluid, Amyloid-beta peptide, Tau protein, Apolipoprotein E (APOE), Settore BIO/12 |
| الوصف: | emerging evidence indicates that apolipoprotein E (APOE) genotype may influence parkinson's disease (PD) course, although clinical and neurochemical correlates have not been completely established. this study aimed to determine the associations of APOE genotypes (& epsilon;4 vs. non-& epsilon;4) with cerebrospinal fluid (CSF) neurodegeneration biomarkers and clinical parameters in early-stage PD patients. one hundred and se-venty-five PD patients and 89 non-neurodegenerative controls grouped in APOE-& epsilon;4 carriers (28 PD; 12 controls) and non-APOE-& epsilon;4 carriers (147 PD; 78 controls) were enrolled. CSF levels of amyloid-& beta;-42, amyloid-& beta;-40, total and 181-phosphorylated tau, and clinical scores were compared among groups adjusting for main covariates. APOE genotypes prevalence was similar in PD and controls. PD APOE-& epsilon;4 carriers had lower amyloid-& beta;-42 CSF levels than PD non-APOE-& epsilon;4 carriers and controls, independently from age. PD APOE-& epsilon;4 carriers also had higher total and "item 5" (attention and memory) non-motor symptoms scale scores than PD non-APOE-& epsilon;4 carriers, independently from confounding factors. APOE-& epsilon;4 genotype might thus account for a more vulnerable PD subtype characterized by prominent amyloidopathy and a greater burden of non -motor symptoms in the early disease stages.data availability: data are available upon reasonable request.& COPY; 2023 the author(s). published by Elsevier Inc. this is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37572524; info:eu-repo/semantics/altIdentifier/wos/WOS:001066105400001; volume:131; firstpage:24; lastpage:28; numberofpages:5; journal:NEUROBIOLOGY OF AGING; https://hdl.handle.net/2108/352048; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85166776552 |
| DOI: | 10.1016/j.neurobiolaging.2023.07.011 |
| الاتاحة: | https://hdl.handle.net/2108/352048 https://doi.org/10.1016/j.neurobiolaging.2023.07.011 |
| رقم الانضمام: | edsbas.77F539D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neurobiolaging.2023.07.011 |
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