Academic Journal
The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review
| العنوان: | The Possible Precipitating Role of SARS-CoV-2 in a Case of Late-Onset Hemichorea Due to a Hyperosmolar Hyperglycemic State: Case Report and Brief Literature Review |
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| المؤلفون: | Sperotto, Roberto, Ceccarelli, Laura, Tereshko, Yan, Merlino, Giovanni, Gigli, Gian Luigi, Valente, Mariarosaria |
| المساهمون: | Sperotto, Roberto, Ceccarelli, Laura, Tereshko, Yan, Merlino, Giovanni, Gigli, Gian Luigi, Valente, Mariarosaria |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Udine: CINECA IRIS |
| مصطلحات موضوعية: | choreic movement, delayed-onset hemichorea, hyperkinetic syndrome, hyperosmolar hyperglycemic hemichorea, movement disorder, movement disorder and COVID-19, nonketotic hyperosmolar hyperglycemic state |
| الوصف: | Case report: An 83-year-old Italian female developed postural instability and gait disturbance associated with a concomitant hyperosmolar hyperglycemic state. Brain CT and MRI scans detected a lesion in the right putamen due to metabolic derangement. A month later, the patient started suffering from choreic movements along the left side of the body with brachio-crural distribution, approximately three weeks after SARS-CoV-2 infection. She was treated with tetrabenazine with complete resolution of the aberrant movements. Any attempt to reduce tetrabenazine caused a relapse of the symptoms. Discussion: In diabetic patients, choreic syndrome should be considered a rare event with a benign prognosis and favorable response to treatment. It is the result of a condition known as "diabetic striatopathy". The association of new-onset choreic movements, an episode of hyperglycemia, and a basal ganglia lesion is suggestive of this condition. Its pathophysiology remains unclear, and a lot of hypotheses are still debated. SARS-CoV-2 might have played a role in triggering the patient's motor symptoms. Conclusions: Our case report agrees with the general features of those reported in the literature about movement disorders in diabetic patients. The late onset of symptoms and the poor response to treatment seem to be atypical characteristics of the syndrome. Although speculative, we cannot exclude the role of SARS-CoV-2. This case can be added to the literature for further studies and reviews. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:59; issue:11; journal:MEDICINA; https://hdl.handle.net/11390/1267956; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85177730603 |
| DOI: | 10.3390/medicina59111949 |
| الاتاحة: | https://hdl.handle.net/11390/1267956 https://doi.org/10.3390/medicina59111949 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.77E2D7C5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/medicina59111949 |
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