Academic Journal
CIRCULATING MIR-132, MIR-146A, MIR-222, AND MIR-320 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF WOMEN WITH POLYCYSTIC OVARY SYNDROME
| العنوان: | CIRCULATING MIR-132, MIR-146A, MIR-222, AND MIR-320 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF WOMEN WITH POLYCYSTIC OVARY SYNDROME |
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| المؤلفون: | Soyman, Z., Durmus, S., Ates, S., Simsek, G., Sozer, V, Kundaktepe, B. P., Uzun, H. |
| بيانات النشر: | Editura Acad Romane |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Polycystic ovary syndrome, miR-132, miR-146a, miR-222, Micrornas, Identification, Steroidogenesis, Profile, Health, Serum |
| الوصف: | Purpose. The aim of the study was to investigate whether the circulating miR-132, miR-146a, miR-222, and miR-320 levels are used in the differential diagnosis of women with polycystic ovary syndrome (PCOS) and healthy women. Methods. This prospective case-control study included 50 women with PCOS and age- and body mass index-matched 50 healthy controls. The hormone and lipid profiles, levels of microRNAs (miRNAs), and parameters of carbohydrate metabolism were measured. Results. Expression levels of miRNAs were assessed using the two-step quantitative real-time polymerase chain reaction. Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group. The miR-320 levels did not differ between the two groups. Free testosterone was negatively correlated with miR-132, miR-146a and miR-222. Insulin was negatively correlated with miR-132 and miR-146a. Conclusions. The results of the study revealed that miRNA expression, may suggest a possible distinction between healthy women and PCOS patients. miR-132, miR-146a, and miR-222 may have key functions in the pathogenesis of PCOS. ; Istanbul University Research Fund [20045] ; This work was supported by the Istanbul University Research Fund (Project No: 20045). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1841-0987 1843-066X |
| Relation: | Acta Endocrinologica-Bucharest; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4183/aeb.2022.13; https://hdl.handle.net/20.500.12831/8697; 18; 13; 19; WOS:000850761500002; 2-s2.0-85135579887 |
| DOI: | 10.4183/aeb.2022.13 |
| الاتاحة: | https://doi.org/10.4183/aeb.2022.13 https://hdl.handle.net/20.500.12831/8697 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.77CD81EC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18410987 1843066X |
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| DOI: | 10.4183/aeb.2022.13 |