التفاصيل البيبلوغرافية
| العنوان: |
Data that underlies Fig 4A–4D and 4G, and 4H. |
| المؤلفون: |
Sarah E. Hadyniak, Joanna F. D. Hagen, Kiara C. Eldred, Boris Brenerman, Katarzyna A. Hussey, Rajiv C. McCoy, Michael E. G. Sauria, James A. Kuchenbecker, Thomas Reh, Ian Glass, Maureen Neitz, Jay Neitz, James Taylor, Robert J. Johnston Jr |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Evolutionary Biology, Developmental Biology, Mental Health, Biological Sciences not elsewhere classified, poorly understood choice, old world monkeys, developing peripheral region, determine mechanisms specifying, human population sample, adult human tissue, l cone subtypes, div >< p, highly expressed early, l cones compared, cone fate early, l cones across, cone fate, human green, l cones, highly similar, cones make, retinoic acid, retinal organoids |
| الوصف: |
Trichromacy is unique to primates among placental mammals, enabled by blue (short/S), green (medium/M), and red (long/L) cones. In humans, great apes, and Old World monkeys, cones make a poorly understood choice between M and L cone subtype fates. To determine mechanisms specifying M and L cones, we developed an approach to visualize expression of the highly similar M- and L-opsin mRNAs. M-opsin was observed before L-opsin expression during early human eye development, suggesting that M cones are generated before L cones. In adult human tissue, the early-developing central retina contained a mix of M and L cones compared to the late-developing peripheral region, which contained a high proportion of L cones. Retinoic acid (RA)-synthesizing enzymes are highly expressed early in retinal development. High RA signaling early was sufficient to promote M cone fate and suppress L cone fate in retinal organoids. Across a human population sample, natural variation in the ratios of M and L cone subtypes was associated with a noncoding polymorphism in the NR2F2 gene, a mediator of RA signaling. Our data suggest that RA promotes M cone fate early in development to generate the pattern of M and L cones across the human retina. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Data_that_underlies_Fig_4A_4D_and_4G_and_4H_/24983651 |
| DOI: |
10.1371/journal.pbio.3002464.s011 |
| الاتاحة: |
https://doi.org/10.1371/journal.pbio.3002464.s011
https://figshare.com/articles/dataset/Data_that_underlies_Fig_4A_4D_and_4G_and_4H_/24983651 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.77BD8872 |
| قاعدة البيانات: |
BASE |