Academic Journal
Increased phospho-AKT in blood cells from LRRK2 G2019S mutation carriers
| العنوان: | Increased phospho-AKT in blood cells from LRRK2 G2019S mutation carriers |
|---|---|
| المؤلفون: | Garrido, Alicia, Pérez-Sisqués, Leticia, Simonet, Cristina, Campoy-Campos, Genís, Solana-Balaguer, Júlia, Martín-Flores, Núria, Fernández, Manel, Soto, Marta, Obiang, Donina, Cámara, Ana, Valldeoriola, Francesc, Muñoz, Esteban, Compta, Yaroslau, Pérez-Navarro, Esther, Alberch, Jordi, Tolosa, Eduardo, Martí, María-José, Ezquerra, Mario, Malagelada, Cristina, Fernández-Santiago, Rubén |
| المصدر: | Annals of Neurology , 92 (5) pp. 888-894. (2022) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | LRRK2, Parkinson's disease, Phospho-AKT, biomarker, blood cells, inflammation |
| الوصف: | The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from patients with G2019S LRRK2-associated PD (L2PD, n = 31), G2019S LRRK2 non-manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P-Ser-935-LRRK2 between groups but detected a specific increase of P-Ser-473-AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P-Ser-473-AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888–894 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10154276/2/Martin%20Flores_Annals%20of%20Neurology%20-%202022%20-%20Garrido%20-%20Increased%20Phospho%E2%80%90AKT%20in%20Blood%20Cells%20from%20LRRK2%20G2019S%20Mutation%20Carriers.pdf; https://discovery.ucl.ac.uk/id/eprint/10154276/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10154276/2/Martin%20Flores_Annals%20of%20Neurology%20-%202022%20-%20Garrido%20-%20Increased%20Phospho%E2%80%90AKT%20in%20Blood%20Cells%20from%20LRRK2%20G2019S%20Mutation%20Carriers.pdf https://discovery.ucl.ac.uk/id/eprint/10154276/ |
| Rights: | open |
| رقم الانضمام: | edsbas.77A59BB5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |