التفاصيل البيبلوغرافية
| العنوان: |
Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| المؤلفون: |
Max Yano, John C. Byrd, Natarajan Muthusamy |
| المصدر: |
Cancers; Volume 14; Issue 23; Pages: 5787 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
cancer, leukemia, CLL, chronic lymphocytic leukemia, NK cell, natural killer cell, immunotherapy, adoptive cellular therapy, cell therapy |
| الوصف: |
Immunotherapy approaches have advanced rapidly in recent years. While the greatest therapeutic advances so far have been achieved with T cell therapies such as immune checkpoint blockade and CAR-T, recent advances in NK cell therapy have highlighted the therapeutic potential of these cells. Chronic lymphocytic leukemia (CLL), the most prevalent form of leukemia in Western countries, is a very immunosuppressive disease but still shows significant potential as a target of immunotherapy, including NK-based therapies. In addition to their antileukemia potential, NK cells are important immune effectors in the response to infections, which represent a major clinical concern for CLL patients. Here, we review the interactions between NK cells and CLL, describing functional changes and mechanisms of CLL-induced NK suppression, interactions with current therapeutic options, and the potential for therapeutic benefit using NK cell therapies. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Cancer Immunology and Immunotherapy; https://dx.doi.org/10.3390/cancers14235787 |
| DOI: |
10.3390/cancers14235787 |
| الاتاحة: |
https://doi.org/10.3390/cancers14235787 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.778AD58D |
| قاعدة البيانات: |
BASE |