التفاصيل البيبلوغرافية
| العنوان: |
The Formation and Function of Birnaviridae Virus Factories |
| المؤلفون: |
Andrew J. Brodrick, Andrew J. Broadbent |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8471 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Birnaviridae, birnavirus, infectious bursal disease virus (IBDV), liquid–liquid phase separation (LLPS), biomolecular condensate, virus factory (VF) |
| جغرافية الموضوع: |
agris |
| الوصف: |
The use of infectious bursal disease virus (IBDV) reverse genetics to engineer tagged reporter viruses has revealed that the virus factories (VFs) of the Birnaviridae family are biomolecular condensates that show properties consistent with liquid–liquid phase separation (LLPS). Although the VFs are not bound by membranes, it is currently thought that viral protein 3 (VP3) initially nucleates the formation of the VF on the cytoplasmic leaflet of early endosomal membranes, and likely drives LLPS. In addition to VP3, IBDV VFs contain VP1 (the viral polymerase) and the dsRNA genome, and they are the sites of de novo viral RNA synthesis. Cellular proteins are also recruited to the VFs, which are likely to provide an optimal environment for viral replication; the VFs grow due to the synthesis of the viral components, the recruitment of other proteins, and the coalescence of multiple VFs in the cytoplasm. Here, we review what is currently known about the formation, properties, composition, and processes of these structures. Many open questions remain regarding the biophysical nature of the VFs, as well as the roles they play in replication, translation, virion assembly, viral genome partitioning, and in modulating cellular processes. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Immunology; https://dx.doi.org/10.3390/ijms24108471 |
| DOI: |
10.3390/ijms24108471 |
| الاتاحة: |
https://doi.org/10.3390/ijms24108471 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.7760A438 |
| قاعدة البيانات: |
BASE |